Equilibrium disorder

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VeDDRA Code: 371

79 adverse event reports referencing this reaction

79
Total Reports
15
Deaths
1900.0%
Death Rate

Species Most Affected

Dog 58
Cat 17
Human 2
Chicken 1
Pig 1

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 6
Shepherd Dog - German 4
Collie - Border 4
Shih Tzu 4
Unknown 3
Crossbred Canine/dog 3
Pug 3
Sheepdog - Shetland 2
American Pit Bull Terrier 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Fluralaner 13.64% 12-Week Chew 5
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 4
Bedinvetmab 4
Spinosad 3
Ivermectin + Pyrantel As Pamoate Salt 3
Afoxolaner 68 Mg Chewable Tablets 3
Betamethasone + Florfenicol + Terbinafine 3
Prednisone 3
Selamectin;Sarolaner 3
Afoxolaner 3
Praziquantel + Pyrantel Pamoate 2
Ivermectin 2
Lufenuron + Milbemycin Oxime 2
Maropitant Citrate 2
Verdinexor 2
Florfenicol + Mometasone Furoate + Terbinafine 2
Terbutaline 2
Doxycycline 2
Hycodan 2

Data Summary

Metric Value
Total reports referencing reaction 79
Reports with fatal outcome 15
Case-fatality rate (reported events) 1900.0%
Species observed 5
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 371.

Equilibrium disorder Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 79 adverse event reports that reference Equilibrium disorder as a reaction term, including 15 reports with a death outcome — a 1900.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 371, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Equilibrium disorder appears most frequently in reports for Dog (58 reports), Cat (17 reports), Human (2 reports) — with Dog dominating at 58 entries. Within those species, the breeds most often named alongside this reaction are Domestic Shorthair (10), Retriever - Labrador (6), Shepherd Dog - German (4). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Equilibrium disorder are Milbemycin Oxime + Spinosad (12 reports), Fluralaner 13.64% 12-Week Chew (5 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (4 reports), Bedinvetmab (4 reports), with Milbemycin Oxime + Spinosad appearing alongside this reaction in 12 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial