Reaction profile

The FDA adverse-event record for equilibrium disorder

79 FDA adverse-event reports reference equilibrium disorder (VeDDRA 371). See the species, breeds, and drugs most associated with it below.

79
reports citing this reaction
19.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
79
Total Reports
15
Deaths
19.0%
Death Rate

Species Most Affected

Dog 58
Cat 17
Human 2
Chicken 1
Pig 1

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 6
Shepherd Dog - German 4
Collie - Border 4
Shih Tzu 4
Unknown 3
Crossbred Canine/dog 3
Pug 3
Sheepdog - Shetland 2
American Pit Bull Terrier 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Fluralaner 13.64% 12-Week Chew 5
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 4
Bedinvetmab 4
Spinosad 3
Ivermectin + Pyrantel As Pamoate Salt 3
Afoxolaner 68 Mg Chewable Tablets 3
Betamethasone + Florfenicol + Terbinafine 3
Prednisone 3
Selamectin;Sarolaner 3
Afoxolaner 3
Praziquantel + Pyrantel Pamoate 2
Ivermectin 2
Lufenuron + Milbemycin Oxime 2
Maropitant Citrate 2
Verdinexor 2
Florfenicol + Mometasone Furoate + Terbinafine 2
Terbutaline 2
Doxycycline 2
Hycodan 2

Equilibrium disorder Reaction Insights

79 reports name Equilibrium disorder; 15 recorded a death outcome (19.0% of reported events, not a population-level mortality rate). VeDDRA code: 371.

By species: Dog (58 reports), Cat (17 reports), Human (2 reports). By breed: Domestic Shorthair (10), Retriever - Labrador (6), Shepherd Dog - German (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (12 reports), Fluralaner 13.64% 12-Week Chew (5 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (4 reports), Bedinvetmab (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.