Reaction profile

The FDA adverse-event record for abnormal electrocardiogram (ecg)

70 FDA adverse-event reports reference abnormal electrocardiogram (ecg) (VeDDRA 2158). See the species, breeds, and drugs most associated with it below.

70
reports citing this reaction
27.1%
death-coded share
Dog
most-affected species
Dexmedetomidine Hydrochloride
most-associated drug
Verify with FDA CVM →
70
Total Reports
19
Deaths
27.1%
Death Rate

Species Most Affected

Dog 53
Cat 15
Horse 2

Breeds Most Affected

Domestic Shorthair 11
Retriever - Golden 5
Crossbred Canine/dog 4
Spaniel (unspecified) 3
Pointing Dog - German Short-haired 3
Chihuahua 2
Dog (unknown) 2
Maltese 2
Retriever - Labrador 2
Domestic Mediumhair 2

Associated Drugs

Dexmedetomidine Hydrochloride 12
Isoflurane 12
Maropitant Citrate 10
Butorphanol 8
Gabapentin 7
Methadone 7
Propofol 6
Robenacoxib 6
Maropitant 6
Carprofen 6
Meloxicam 6
Enrofloxacin 6
Diazepam 5
Ketamine 5
Buprenorphine 5
Alfaxalone 5
Trazodone 5
Oxygen 5
Doxycycline 5
Oclacitinib Maleate 5

Abnormal electrocardiogram (ECG) Reaction Insights

70 reports name Abnormal electrocardiogram (ECG); 19 recorded a death outcome (27.1% of reported events, not a population-level mortality rate). VeDDRA code: 2158.

By species: Dog (53 reports), Cat (15 reports), Horse (2 reports). By breed: Domestic Shorthair (11), Retriever - Golden (5), Crossbred Canine/dog (4).

Most co-reported drugs: Dexmedetomidine Hydrochloride (12 reports), Isoflurane (12 reports), Maropitant Citrate (10 reports), Butorphanol (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.