Reaction profile

The FDA adverse-event record for increased intra-ocular pressure

86 FDA adverse-event reports reference increased intra-ocular pressure (VeDDRA 2234). See the species, breeds, and drugs most associated with it below.

86
reports citing this reaction
19.8%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
86
Total Reports
17
Deaths
19.8%
Death Rate

Species Most Affected

Dog 70
Cat 15
Rabbit 1

Breeds Most Affected

Domestic Shorthair 13
Shih Tzu 9
Retriever - Labrador 5
Spaniel - Cocker American 4
Collie - Border 3
Bulldog - French 3
Pug 2
Terrier (unspecified) 2
Bulldog 2
Schnauzer - Miniature 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 8
Prednisone 8
Maropitant Citrate 6
Moxidectin 6
Pyrantel Pamoate;Sarolaner 6
Diphenhydramine 5
Fluralaner Chew Tablets 5
Cefovecin Sodium 5
Metronidazole 4
Carprofen 4
Meloxicam 4
Doxycycline 4
Bedinvetmab 4
Milbemycin Oxime + Spinosad 3
Grapiprant 3
Atipamezole Hydrochloride 3
Trilostane 3
Insulin Injectable Vial 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Isoflurane 3

Increased intra-ocular pressure Reaction Insights

86 reports name Increased intra-ocular pressure; 17 recorded a death outcome (19.8% of reported events, not a population-level mortality rate). VeDDRA code: 2234.

By species: Dog (70 reports), Cat (15 reports), Rabbit (1 reports). By breed: Domestic Shorthair (13), Shih Tzu (9), Retriever - Labrador (5).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (8 reports), Prednisone (8 reports), Maropitant Citrate (6 reports), Moxidectin (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.