Reaction profile

The FDA adverse-event record for hypopigmentation

67 FDA adverse-event reports reference hypopigmentation (VeDDRA 915). See the species, breeds, and drugs most associated with it below.

67
reports citing this reaction
4.5%
death-coded share
Dog
most-affected species
Toceranib Phosphate
most-associated drug
Verify with FDA CVM →
67
Total Reports
3
Deaths
4.5%
Death Rate

Species Most Affected

Dog 57
Cat 5
Human 3
Horse 2

Breeds Most Affected

Retriever - Labrador 7
Shepherd Dog - German 6
Unknown 3
Sheepdog - Shetland 3
Crossbred Canine/dog 3
Pug 3
Schnauzer (unspecified) 2
Horse (unknown) 2
Domestic Shorthair 2
Mixed (Dog) 2

Associated Drugs

Toceranib Phosphate 12
Oclacitinib Maleate 10
Selamectin 8
Cefovecin Sodium 5
Fluralaner Chew Tablets 5
Gabapentin 5
Carprofen 4
Imidacloprid + Moxidectin 4
Vitamins 4
Prednisone 4
Milbemycin Oxime + Spinosad 4
Maropitant Citrate 4
Doxycycline 3
Cefpodoxime Proxetil 3
Cefovecin 3
Thiabendazole + Dexamethasone + Neomycin 3
Hypoallergenic Veterinary Diet 3
Ear Cleansing Solution 3
Dexmedetomidine 3
Cyclosporine 3

Hypopigmentation Reaction Insights

67 reports name Hypopigmentation; 3 recorded a death outcome (4.5% of reported events, not a population-level mortality rate). VeDDRA code: 915.

By species: Dog (57 reports), Cat (5 reports), Human (3 reports). By breed: Retriever - Labrador (7), Shepherd Dog - German (6), Unknown (3).

Most co-reported drugs: Toceranib Phosphate (12 reports), Oclacitinib Maleate (10 reports), Selamectin (8 reports), Cefovecin Sodium (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.