Reaction profile

The FDA adverse-event record for skin reaction nos

126 FDA adverse-event reports reference skin reaction nos (VeDDRA 2876). See the species, breeds, and drugs most associated with it below.

126
reports citing this reaction
4.8%
death-coded share
Dog
most-affected species
Frunevetmab
most-associated drug
Verify with FDA CVM →
126
Total Reports
6
Deaths
4.8%
Death Rate

Species Most Affected

Dog 85
Cat 37
Human 3
Unknown 1

Breeds Most Affected

Domestic Shorthair 19
Dog (unknown) 15
Retriever - Labrador 6
Retriever - Golden 6
Unknown 5
Domestic Longhair 5
Crossbred Canine/dog 3
Collie (unspecified) 3
Cat (other) 3
Shepherd Dog - German 3

Associated Drugs

Frunevetmab 16
Lotilaner 12
Fluralaner 13.64% 12-Week Chew 11
Oclacitinib Maleate 9
Gabapentin 9
Carprofen 8
Prednisone 7
Milbemycin Oxime + Praziquantel 7
Ivermectin + Pyrantel As Pamoate Salt 6
Selamectin;Sarolaner 6
Enrofloxacin 6
Bedinvetmab 6
Imidacloprid, Flumethrin 5
Afoxolaner 5
Buprenorphine 5
Pyrantel Pamoate;Sarolaner 5
Rabies Vaccine 4
Nitenpyram 4
Cyclosporine 4
Cefovecin 4

Skin reaction NOS Reaction Insights

126 reports name Skin reaction NOS; 6 recorded a death outcome (4.8% of reported events, not a population-level mortality rate). VeDDRA code: 2876.

By species: Dog (85 reports), Cat (37 reports), Human (3 reports). By breed: Domestic Shorthair (19), Dog (unknown) (15), Retriever - Labrador (6).

Most co-reported drugs: Frunevetmab (16 reports), Lotilaner (12 reports), Fluralaner 13.64% 12-Week Chew (11 reports), Oclacitinib Maleate (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.