Reaction profile

The FDA adverse-event record for skin reaction nos

141 FDA adverse-event reports reference skin reaction nos (VeDDRA 2876). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1225 of 2,481
by report volume (all reactions)
141
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin reaction NOS has 141 reports now versus 135 in that prior snapshot: 6 more (4.4%).

Report change
+6
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin reaction NOS changes

FDA AER · VeDDRA plate

Code 2876 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 141 reports
  • DEATH-LOW 4.3%
  • MID-PACK #1225/2481
  • PHOTO-FINISH Obtunded
  • SPECIES-DOG Dog · 96
  • DRUG-LEAD Frunevetmab · 16
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Obtunded (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Skin reaction NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Difficulty eating NOS · near142Involuntary urination · near142Obtunded · near141Skin reaction NOS · this rea…141Dehiscence, medical d… · near140Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin reaction NOS

Skin reaction NOS: low death-coded share in the FDA AER plate

Signature read: Skin reaction NOS's 4.3% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 6 of 141 reports (4.3% of named reports). Nearest volume peer: Obtunded (±0 reports). Lead species Dog (96). Lead co-reported drug Frunevetmab (16).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Frunevetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 96
Cat 39
Human 4
Unknown 1
Cattle 1

Breeds Most Affected

Domestic Shorthair 21
Dog (unknown) 15
Retriever - Labrador 7
Retriever - Golden 7
Unknown 6
Crossbred Canine/dog 5
Domestic Longhair 5
Pit Bull 4
Terrier - Bull - American Pit 3
Collie (unspecified) 3

Associated Drugs

Frunevetmab 16
Lotilaner 13
Fluralaner 13.64% 12-Week Chew 12
Oclacitinib Maleate 9
Gabapentin 9
Milbemycin Oxime + Praziquantel 8
Carprofen 8
Prednisone 7
Selamectin;Sarolaner 7
Buprenorphine 6
Ivermectin + Pyrantel As Pamoate Salt 6
Enrofloxacin 6
Pyrantel Pamoate;Sarolaner 6
Bedinvetmab 6
Imidacloprid, Flumethrin 5
Rabies Vaccine 5
Afoxolaner 5
Diphenhydramine 5
Nitenpyram 4
Cyclosporine 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Skin reaction NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (141 here).

Similar death-coded share

Nearest other reactions by death-coded share (4.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin reaction NOS (#1225 of 2,481 by report volume); death-coded 4.3%. PlainBreed reaction plate · death-coded share stamp 4.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →