Reaction profile

The FDA adverse-event record for dullness

709 FDA adverse-event reports reference dullness (VeDDRA 126). See the species, breeds, and drugs most associated with it below.

709
reports citing this reaction
33.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
709
Total Reports
235
Deaths
33.1%
Death Rate

Species Most Affected

Dog 574
Cat 109
Horse 19
Cattle 3
Pig 1
Other Bovine 1
Goat 1
Reindeer 1

Breeds Most Affected

Domestic Shorthair 57
Retriever - Labrador 42
Crossbred Canine/dog 38
Boxer (German Boxer) 28
Terrier - Yorkshire 28
Chihuahua 24
Retriever - Golden 23
Shih Tzu 20
Pug 15
Maltese 15

Associated Drugs

Milbemycin Oxime + Spinosad 152
Maropitant Citrate 73
Fluralaner Chew Tablets 41
Spinosad 38
Carprofen 36
Moxidectin 34
Bedinvetmab 33
Cefovecin 29
Ivermectin 28
Trilostane 25
Prednisone 25
Gabapentin 24
Buprenorphine 22
Pyrantel Pamoate;Sarolaner 22
Afoxolaner 21
Fluralaner 13.64% 12-Week Chew 20
Meloxicam 19
Famotidine 17
Oclacitinib Maleate 16
Butorphanol 15

Dullness Reaction Insights

709 reports name Dullness; 235 recorded a death outcome (33.1% of reported events, not a population-level mortality rate). VeDDRA code: 126.

By species: Dog (574 reports), Cat (109 reports), Horse (19 reports). By breed: Domestic Shorthair (57), Retriever - Labrador (42), Crossbred Canine/dog (38).

Most co-reported drugs: Milbemycin Oxime + Spinosad (152 reports), Maropitant Citrate (73 reports), Fluralaner Chew Tablets (41 reports), Spinosad (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.