Reaction profile

The FDA adverse-event record for dullness

739 FDA reports name dullness, a high-volume reaction in the CVM extract (VeDDRA 126). Plate stamps and neighbourhood peers follow.

#486 of 2,481
by report volume (all reactions)
739
reports citing this reaction
33.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dullness has 739 reports now versus 728 in that prior snapshot: 11 more (1.5%).

Report change
+11
Death-coded reports
+8
Death-coded share
+0.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dullness changes

FDA AER · VeDDRA plate

Code 126 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 739 reports
  • DEATH-HOT 33.8%
  • UPPER-Q #486/2481
  • PHOTO-FINISH Chewing - pruritus (s…
  • SPECIES-DOG Dog · 591
  • DRUG-LEAD Milbemycin Oxime… · 152
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Chewing - pruritus (see also 'Oral cavity disorders') (±4 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Dullness

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Dullness · this reaction739Chewing - pruritus (s… · near735Contamination, Partic… · near731Application site pain · near729Generalised weakness · near729Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Dullness

Dullness: high death-coded share in the FDA AER plate

Signature read: 250 death-coded reports is a heavy tail count for Dullness in the CVM extract. Report volume is upper-third scale: 739 named reports in the openFDA extract. Death-coded share is upper-third: 250 of 739 reports (33.8% of named reports). Nearest volume peer: Chewing - pruritus (see also 'Oral cavity disorders') (±4 reports). Lead species Dog (591). Lead co-reported drug Milbemycin Oxime + Spinosad (152).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 591
Cat 120
Horse 21
Cattle 3
Pig 1
Other Bovine 1
Goat 1
Reindeer 1

Breeds Most Affected

Domestic Shorthair 65
Retriever - Labrador 42
Crossbred Canine/dog 39
Terrier - Yorkshire 31
Boxer (German Boxer) 28
Chihuahua 25
Retriever - Golden 24
Shih Tzu 22
Pug 16
Maltese 15

Associated Drugs

Milbemycin Oxime + Spinosad 152
Maropitant Citrate 77
Fluralaner Chew Tablets 41
Spinosad 38
Moxidectin 37
Bedinvetmab 37
Carprofen 36
Cefovecin 29
Ivermectin 28
Gabapentin 27
Trilostane 26
Prednisone 25
Pyrantel Pamoate;Sarolaner 25
Buprenorphine 23
Meloxicam 22
Afoxolaner 22
Fluralaner 13.64% 12-Week Chew 20
Oclacitinib Maleate 19
Famotidine 18
Butorphanol 15

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Dullness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (33.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dullness (#486 of 2,481 by report volume); death-coded 33.8%. PlainBreed reaction plate · death-coded report count stamp 250 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →