Reaction profile

The FDA adverse-event record for contamination, particulate matter

694 FDA adverse-event reports reference contamination, particulate matter (VeDDRA 99846). See the species, breeds, and drugs most associated with it below.

694
reports citing this reaction
0.4%
death-coded share
Unknown
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
694
Total Reports
3
Deaths
0.4%
Death Rate

Species Most Affected

Unknown 673
Dog 18
Cat 3

Breeds Most Affected

Unknown 676
Crossbred Canine/dog 4
Dog (unknown) 3
Retriever - Labrador 2
Hound (unspecified) 1
Cat (unknown) 1
Bichon Frise 1
Siamese 1
Spitz - American Eskimo Dog 1
Terrier - West Highland White 1

Associated Drugs

Moxidectin 116
Insulin Injectable Vial 96
Cefovecin 43
Enrofloxacin 35
Amprolium 35
Flunixin Meglumine Injectable 28
Propofol 25
Triamcinolone Acetonide 18
Hyaluronate Sodium 18
Maropitant Citrate 16
Carprofen 16
Furosemide Injection 13
Polysulfated Glycosaminoglycan 9
Meloxicam 9
Butorphanol Injectable 9
Robenacoxib 9
Ceftiofur Sodium 8
Bupivacaine 8
Maropitant 7
Amprolium Ion 6

Contamination, Particulate Matter Reaction Insights

694 reports name Contamination, Particulate Matter; 3 recorded a death outcome (0.4% of reported events, not a population-level mortality rate). VeDDRA code: 99846.

By species: Unknown (673 reports), Dog (18 reports), Cat (3 reports). By breed: Unknown (676), Crossbred Canine/dog (4), Dog (unknown) (3).

Most co-reported drugs: Moxidectin (116 reports), Insulin Injectable Vial (96 reports), Cefovecin (43 reports), Enrofloxacin (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.