Reaction profile

The FDA adverse-event record for discomfort nos

1,037 FDA adverse-event reports reference discomfort nos (VeDDRA 2498). See the species, breeds, and drugs most associated with it below.

1,037
reports citing this reaction
10.8%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,037
Total Reports
112
Deaths
10.8%
Death Rate

Species Most Affected

Dog 849
Cat 142
Horse 28
Cattle 6
Human 4
Goat 2
Unknown 1
Sheep 1
Hedgehog 1
Other 1

Breeds Most Affected

Domestic Shorthair 82
Retriever - Labrador 78
Crossbred Canine/dog 64
Chihuahua 51
Retriever - Golden 39
Dog (unknown) 33
Terrier - Yorkshire 29
Shih Tzu 29
Shepherd Dog - German 23
Boxer (German Boxer) 22

Associated Drugs

Carprofen 87
Gabapentin 81
Bedinvetmab 70
Afoxolaner 69
Moxidectin 61
Melarsomine Dihydrochloride 58
Maropitant Citrate 56
Tigilanol Tiglate 56
Milbemycin Oxime + Spinosad 53
Prednisone 52
Pyrantel Pamoate;Sarolaner 41
Oclacitinib Maleate 40
Ivermectin + Pyrantel As Pamoate Salt 37
Fluralaner Chew Tablets 33
Grapiprant 32
Butorphanol 31
Cefovecin 28
Anti-Il31 Mab Mcs Lot #1283563 28
Trilostane 27
Buprenorphine 27

Discomfort NOS Reaction Insights

1,037 reports name Discomfort NOS; 112 recorded a death outcome (10.8% of reported events, not a population-level mortality rate). VeDDRA code: 2498.

By species: Dog (849 reports), Cat (142 reports), Horse (28 reports). By breed: Domestic Shorthair (82), Retriever - Labrador (78), Crossbred Canine/dog (64).

Most co-reported drugs: Carprofen (87 reports), Gabapentin (81 reports), Bedinvetmab (70 reports), Afoxolaner (69 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.