Reaction profile

The FDA adverse-event record for eye disorder nos (for photophobia see 'neurological')

2,204 FDA adverse-event reports reference eye disorder nos (for photophobia see 'neurological') (VeDDRA 452). See the species, breeds, and drugs most associated with it below.

2,204
reports citing this reaction
10.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,204
Total Reports
224
Deaths
10.2%
Death Rate

Species Most Affected

Dog 1,795
Cat 315
Human 45
Cattle 29
Horse 11
Unknown 2
Sheep 2
Goat 2
Chicken 1
Other Mammals 1

Breeds Most Affected

Domestic Shorthair 154
Retriever - Labrador 146
Crossbred Canine/dog 126
Chihuahua 92
Boxer (German Boxer) 91
Shih Tzu 87
Retriever - Golden 74
Terrier - Yorkshire 60
Unknown 51
Shepherd Dog - German 50

Associated Drugs

Milbemycin Oxime + Spinosad 652
Spinosad 201
Carprofen 115
Selamectin 105
Oclacitinib Maleate 85
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 81
Maropitant Citrate 80
Afoxolaner 75
Imidacloprid + Moxidectin 67
Ivermectin 56
Prednisone 56
Enrofloxacin 53
Moxidectin 53
Fluralaner Chew Tablets 51
Milbemycin Oxime + Praziquantel 48
Ivermectin + Pyrantel As Pamoate Salt 46
Cefovecin 44
Sarolaner 43
Trilostane 41
Pyrantel Pamoate;Sarolaner 41

Eye disorder NOS (for photophobia see 'neurological') Reaction Insights

2,204 reports name Eye disorder NOS (for photophobia see 'neurological'); 224 recorded a death outcome (10.2% of reported events, not a population-level mortality rate). VeDDRA code: 452.

By species: Dog (1,795 reports), Cat (315 reports), Human (45 reports). By breed: Domestic Shorthair (154), Retriever - Labrador (146), Crossbred Canine/dog (126).

Most co-reported drugs: Milbemycin Oxime + Spinosad (652 reports), Spinosad (201 reports), Carprofen (115 reports), Selamectin (105 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.