Reaction profile

The FDA adverse-event record for self trauma

1,378 FDA adverse-event reports reference self trauma (VeDDRA 125). See the species, breeds, and drugs most associated with it below.

1,378
reports citing this reaction
2.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,378
Total Reports
27
Deaths
2.0%
Death Rate

Species Most Affected

Dog 1,118
Cat 246
Horse 9
Unknown 2
Human 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 159
Retriever - Labrador 112
Shih Tzu 65
Shepherd Dog - German 63
Crossbred Canine/dog 60
Chihuahua 57
Maltese 43
Retriever - Golden 42
Dog (unknown) 41
Terrier - Yorkshire 38

Associated Drugs

Milbemycin Oxime + Spinosad 281
Afoxolaner 235
Spinosad 155
Ivermectin + Pyrantel As Pamoate Salt 89
Nitenpyram 83
Selamectin 66
Imidacloprid + Moxidectin 59
Fluralaner Chew Tablets 51
Fluralaner Spot-On Solution 37
Afoxolaner 28.3 Mg Chewable Tablets 25
Carprofen 23
Cyclosporine 23
Milbemycin Oxime + Praziquantel 20
Oclacitinib Maleate 19
Ivermectin 18
Frunevetmab 18
Fluralaner 13.64% 12-Week Chew 17
Cefovecin 16
Lotilaner 16
Cyclosporine A 13

Self trauma Reaction Insights

1,378 reports name Self trauma; 27 recorded a death outcome (2.0% of reported events, not a population-level mortality rate). VeDDRA code: 125.

By species: Dog (1,118 reports), Cat (246 reports), Horse (9 reports). By breed: Domestic Shorthair (159), Retriever - Labrador (112), Shih Tzu (65).

Most co-reported drugs: Milbemycin Oxime + Spinosad (281 reports), Afoxolaner (235 reports), Spinosad (155 reports), Ivermectin + Pyrantel As Pamoate Salt (89 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.