Reaction profile

The FDA adverse-event record for cyanosis

1,301 FDA adverse-event reports reference cyanosis (VeDDRA 1009). See the species, breeds, and drugs most associated with it below.

1,301
reports citing this reaction
48.5%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
1,301
Total Reports
631
Deaths
48.5%
Death Rate

Species Most Affected

Dog 938
Cat 324
Horse 16
Cattle 10
Pig 5
Guinea Pig 1
Other 1
Chicken 1
Rat 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 141
Chihuahua 72
Domestic (unspecified) 68
Terrier - Yorkshire 62
Crossbred Canine/dog 52
Bulldog 45
Retriever - Labrador 42
Pug 36
Bulldog - French 36
Shih Tzu 35

Associated Drugs

Moxidectin 161
Dexmedetomidine Hydrochloride 107
Propofol 101
Maropitant Citrate 96
Isoflurane 85
Butorphanol 83
Cefovecin 81
Melarsomine Dihydrochloride 54
Buprenorphine 53
Carprofen 52
Butorphanol Tartrate 51
Ketamine 50
Milbemycin Oxime + Spinosad 49
Dexamethasone 49
Epinephrine 45
Atipamezole Hydrochloride 44
Alfaxalone 44
Melarsomine Dihydrochloride Injection 38
Ketamine Hydrochloride 37
Diphenhydramine Hcl 37

Cyanosis Reaction Insights

1,301 reports name Cyanosis; 631 recorded a death outcome (48.5% of reported events, not a population-level mortality rate). VeDDRA code: 1009.

By species: Dog (938 reports), Cat (324 reports), Horse (16 reports). By breed: Domestic Shorthair (141), Chihuahua (72), Domestic (unspecified) (68).

Most co-reported drugs: Moxidectin (161 reports), Dexmedetomidine Hydrochloride (107 reports), Propofol (101 reports), Maropitant Citrate (96 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.