Reaction profile

The FDA adverse-event record for cyanosis

1,338 FDA reports name cyanosis, a high-volume reaction in the CVM extract (VeDDRA 1009). Plate stamps and neighbourhood peers follow.

#309 of 2,481
by report volume (all reactions)
1,338
reports citing this reaction
48.2%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cyanosis has 1,338 reports now versus 1,325 in that prior snapshot: 13 more (1.0%).

Report change
+13
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cyanosis changes

FDA AER · VeDDRA plate

Code 1009 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,338 reports
  • DEATH-HOT 48.2%
  • UPPER-Q #309/2481
  • PHOTO-FINISH Alopecia NOS
  • SPECIES-DOG Dog · 968
  • DRUG-LEAD Moxidectin · 166
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Alopecia NOS (±3 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Cyanosis

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Cyanosis · this reaction1338Alopecia NOS · near1335Liver disorder NOS · near1335INEFFECTIVE, COCCIDIA · near1334Glazed eye · near1333Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cyanosis

Cyanosis: high death-coded share in the FDA AER plate

Signature read: 645 death-coded reports is a heavy tail count for Cyanosis in the CVM extract. Report volume is upper-third scale: 1,338 named reports in the openFDA extract. Death-coded share is upper-third: 645 of 1,338 reports (48.2% of named reports). Nearest volume peer: Alopecia NOS (±3 reports). Lead species Dog (968). Lead co-reported drug Moxidectin (166).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 968
Cat 330
Horse 16
Cattle 10
Pig 5
Chicken 2
Guinea Pig 1
Other 1
Rat 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 144
Chihuahua 74
Domestic (unspecified) 68
Terrier - Yorkshire 62
Crossbred Canine/dog 53
Bulldog 45
Bulldog - French 44
Retriever - Labrador 43
Shih Tzu 36
Pug 36

Associated Drugs

Moxidectin 166
Dexmedetomidine Hydrochloride 108
Propofol 107
Maropitant Citrate 105
Isoflurane 92
Butorphanol 84
Cefovecin 82
Melarsomine Dihydrochloride 55
Buprenorphine 55
Carprofen 54
Ketamine 53
Butorphanol Tartrate 52
Milbemycin Oxime + Spinosad 49
Dexamethasone 49
Alfaxalone 46
Epinephrine 45
Atipamezole Hydrochloride 44
Melarsomine Dihydrochloride Injection 38
Ketamine Hydrochloride 37
Diphenhydramine Hcl 37

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cyanosis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,338 here).

Alopecia NOS 1,335 Liver disorder NOS 1,335 INEFFECTIVE, COCCIDIA 1,334 Glazed eye 1,333

Similar death-coded share

Nearest other reactions by death-coded share (48.2% here), distinct from the volume row.

Peritoneal fluid, abnormal NOS 48.1% PR-INJECTION SITE, LESION(S) 48.1% Paralysis 48.6% Respiratory tract disorder NOS 48.7%

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cyanosis (#309 of 2,481 by report volume); death-coded 48.2%. PlainBreed reaction plate · death-coded report count stamp 645 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →