Reaction profile

The FDA adverse-event record for female reproductive tract disorder nos

140 FDA adverse-event reports reference female reproductive tract disorder nos (VeDDRA 769). See the species, breeds, and drugs most associated with it below.

140
reports citing this reaction
13.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
140
Total Reports
19
Deaths
13.6%
Death Rate

Species Most Affected

Dog 80
Cattle 28
Horse 8
Human 8
Pig 7
Cat 7
Sheep 1
Other Birds 1

Breeds Most Affected

Retriever - Labrador 11
Holstein-Friesian also known as Holstein 10
Unknown 9
Pig (unknown) 5
Sheepdog - Shetland 4
Aberdeen Angus 4
Dog (unknown) 4
Crossbred Canine/dog 4
Retriever - Golden 4
Tonkinese 4

Associated Drugs

Milbemycin Oxime + Spinosad 24
Spinosad 12
Milbemycin Oxime + Praziquantel 10
Sometribove 8
Monensin Sodium 8
Afoxolaner 8
Trilostane 7
Oclacitinib Maleate 7
Fluralaner Chew Tablets 6
Milbemycin Oxime 5
Estriol Tablets 5
Ivermectin 4
Altrenogest Oily Solution 4
Fluralaner 13.64% 12-Week Chew 4
Progesterone 3
Deslorelin Acetate 3
Carprofen 3
Anti-Il31 Mab Mcs Lot #1283563 3
Lotilaner 3
Ractopamine 2

Female reproductive tract disorder NOS Reaction Insights

140 reports name Female reproductive tract disorder NOS; 19 recorded a death outcome (13.6% of reported events, not a population-level mortality rate). VeDDRA code: 769.

By species: Dog (80 reports), Cattle (28 reports), Horse (8 reports). By breed: Retriever - Labrador (11), Holstein-Friesian also known as Holstein (10), Unknown (9).

Most co-reported drugs: Milbemycin Oxime + Spinosad (24 reports), Spinosad (12 reports), Milbemycin Oxime + Praziquantel (10 reports), Sometribove (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.