Reaction profile

The FDA adverse-event record for application site alopecia

6,842 FDA adverse-event reports reference application site alopecia (VeDDRA 2). See the species, breeds, and drugs most associated with it below.

6,842
reports citing this reaction
1.1%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
6,842
Total Reports
73
Deaths
1.1%
Death Rate

Species Most Affected

Cat 6,414
Dog 390
Cattle 21
Horse 8
Rabbit 5
Camel 1
Other Birds 1
Pig 1
Goat 1

Breeds Most Affected

Domestic Shorthair 3,571
Domestic (unspecified) 942
Domestic Longhair 349
Cat (unknown) 348
Domestic Mediumhair 327
Cat (other) 200
Siamese 150
Maine Coon 118
Bengal 68
Russian 45

Associated Drugs

Selamectin 3,082
Emodepside + Praziquantel 1,127
Imidacloprid + Moxidectin 900
Selamectin;Sarolaner 680
Fluralaner Spot-On Solution 433
Buprenorphine 146
Fluralaner/Moxidectin Spot-On 121
Flumethrin-Imidacloprid 119
Imidacloprid, Moxidectin 108
Emodepside, Praziquantel 86
Rabies Vaccine 82
Cefovecin Sodium 60
Cefovecin 55
Methylprednisolone Acetate 47
Eprinomectin + Esafoxolaner + Praziquantel 43
Rabies 42
Prednisolone 34
Isoflurane 34
Imidacloprid + Pyriproxyfen 33
Maropitant Citrate 33

Application site alopecia Reaction Insights

6,842 reports name Application site alopecia; 73 recorded a death outcome (1.1% of reported events, not a population-level mortality rate). VeDDRA code: 2.

By species: Cat (6,414 reports), Dog (390 reports), Cattle (21 reports). By breed: Domestic Shorthair (3,571), Domestic (unspecified) (942), Domestic Longhair (349).

Most co-reported drugs: Selamectin (3,082 reports), Emodepside + Praziquantel (1,127 reports), Imidacloprid + Moxidectin (900 reports), Selamectin;Sarolaner (680 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.