Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - whipworm

7,126 FDA reports name lack of efficacy (endoparasite) - whipworm, a high-volume reaction in the CVM extract (VeDDRA 2801). Plate stamps and neighbourhood peers follow.

#71 of 2,481
by report volume (all reactions)
7,126
reports citing this reaction
1.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (endoparasite) - whipworm has 7,126 reports now versus 7,014 in that prior snapshot: 112 more (1.6%).

Report change
+112
Death-coded reports
+1
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (endoparasite) - whipworm changes

FDA AER · VeDDRA plate

Code 2801 VOL-HIGH

VOL-HIGH · DEATH-LOW · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 7,126 reports
  • DEATH-LOW 1.0%
  • TOP-DECILE #71/2481
  • PHOTO-FINISH Scratching
  • SPECIES-DOG Dog · 7,100
  • DRUG-LEAD Ivermectin + Pyra… · 1,061
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Scratching (±13 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lack of efficacy - whipworm

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Containers, Leaking · near7289Trembling · near7230Scratching · near7139Lack of efficacy (end… · thi…7126Underfilling, Package · near6969Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (endoparasite) - whipworm

Lack of efficacy (endoparasite) - whipworm: low death-coded share in the FDA AER plate

Signature read: 7,126 reports place Lack of efficacy (endoparasite) - whipworm in the upper third of FDA AER volume (#71 of 2,481). Report volume is upper-third scale: 7,126 named reports in the openFDA extract. Death-coded share is lower-third: 74 of 7,126 reports (1.0% of named reports). Nearest volume peer: Scratching (±13 reports). Lead species Dog (7,100). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (1,061).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 7,100
Cattle 11
Cat 9
Sheep 1
Primate 1
Other 1
Camel 1
Pig 1
Horse 1

Breeds Most Affected

Retriever - Labrador 778
Crossbred Canine/dog 713
Retriever - Golden 477
Shepherd Dog - German 328
Beagle 321
Dachshund (unspecified) 200
Shepherd Dog - Australian 197
Dog (unknown) 190
Collie - Border 158
Schnauzer - Miniature 143

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 1,061
Pyrantel Pamoate;Sarolaner 868
Moxidectin 863
Milbemycin Oxime + Spinosad 862
Milbemycin 566
Milbemycin Oxime + Praziquantel 516
Milbemycin Oxime, Lufenuron 424
Selamectin 302
Lufenuron + Milbemycin Oxime 239
Milbemycin Oxime 231
Imidacloprid + Moxidectin 195
Milbemcyin Oxime, Lufenuron, Praziquantel 157
Milbemycin/Lufenuron/Pzq Chew 130
Milbemycin, Lufenuron 124
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 104
Ivermectin, Pyrantel 103
Milbemycin/Lufenuron Tablets 98
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 62
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 58
Afoxolaner 57

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (endoparasite) - whipworm, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (7,126 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (endoparasite) - whipworm (#71 of 2,481 by report volume); death-coded 1.0%. PlainBreed reaction plate · report volume stamp 7,126 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →