Reaction profile

The FDA adverse-event record for claw / hoof / nail loss

62 FDA adverse-event reports reference claw / hoof / nail loss (VeDDRA 1185). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1630 of 2,481
by report volume (all reactions)
62
reports citing this reaction
14.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Claw / hoof / nail loss has 62 reports now versus 62 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Claw / hoof / nail loss changes

FDA AER · VeDDRA plate

Code 1185 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 62 reports
  • DEATH-ELEV 14.5%
  • MID-PACK #1630/2481
  • PHOTO-FINISH Application site ting…
  • SPECIES-DOG Dog · 53
  • DRUG-LEAD Unspecified · 17
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site tingling (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Claw / hoof / nail loss

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site ting… · near62Claw / hoof / nail lo… · thi…62Desquamation · near62Dropper, Abnormal · near62Eyesight trouble · near62Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Claw / hoof / nail loss

What the FDA AER plate says about Claw / hoof / nail loss

Signature read: report volume at 62 (#1630 of 2,481) is the standout scale stamp on Claw / hoof / nail loss. Report volume sits in the middle third of the reaction corpus. 9 of 62 reports were death-coded (14.5% of named reports, not a population mortality rate). Nearest volume peer: Application site tingling (±0 reports). Lead species Dog (53). Lead co-reported drug Unspecified (17).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Unspecified appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 53
Cat 4
Cattle 3
Horse 1
Turkey 1

Breeds Most Affected

Shepherd Dog - German 8
Retriever - Labrador 8
Terrier (unspecified) 3
Terrier - Boston 2
Beagle 2
Boxer (German Boxer) 2
Dog (unknown) 2
Mastiff (unspecified) 2
Domestic Shorthair 2
Terrier - Bull - Staffordshire 2

Associated Drugs

Unspecified 17
Milbemycin Oxime + Spinosad 6
Oclacitinib Maleate 6
Prednisone 6
Bedinvetmab 6
Afoxolaner 5
Milbemycin Oxime + Praziquantel 5
Carprofen 5
Propofol 5
Gabapentin 5
Diphenhydramine 4
Sarolaner 4
Moxidectin 4
Midazolam 4
Cefovecin Sodium 4
Buprenorphine 4
Ketoconazole,Hydrocortisone 4
Maropitant Citrate 3
Famotidine 3
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Claw / hoof / nail loss, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (62 here).

Similar death-coded share

Nearest other reactions by death-coded share (14.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Claw / hoof / nail loss (#1630 of 2,481 by report volume); death-coded 14.5%. PlainBreed reaction plate · report volume stamp 62 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →