Reaction profile

The FDA adverse-event record for application site tingling

60 FDA adverse-event reports reference application site tingling (VeDDRA 2193). See the species, breeds, and drugs most associated with it below.

60
reports citing this reaction
0.0%
death-coded share
Human
most-affected species
Fluralaner Spot-On Solution
most-associated drug
Verify with FDA CVM →
60
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Human 60

Breeds Most Affected

Unknown 60

Associated Drugs

Fluralaner Spot-On Solution 23
Imidacloprid + Moxidectin 14
Selamectin 7
Fluralaner/Moxidectin Spot-On 6
Unspecified Hand Soap 2
Emodepside + Praziquantel 1
Miconazole Nitrate + Polymyxin B Sulfate + Prednisolone Acetate 1
Mercaptobenzothiazole 1
Tildipirosin Injectable 1
Dexmedetomidine Hydrochloride 1
Unknown Soap 1
Dimethyl Sulfoxide; Fluocinolone Acetonide 1
Unspecified Liquid Dish Soap 1
Soap 1
Enrofloxacin 1
Fluocinolone Acetonide And Dimethyl Sulfoxide 1
Mirtazapine 1
Montelukast 1
Fexofenadine 1
Mesalamine 1

Application site tingling Reaction Insights

60 reports name Application site tingling; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2193.

By species: Human (60 reports). By breed: Unknown (60).

Most co-reported drugs: Fluralaner Spot-On Solution (23 reports), Imidacloprid + Moxidectin (14 reports), Selamectin (7 reports), Fluralaner/Moxidectin Spot-On (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.