Reaction profile

The FDA adverse-event record for teeth grinding

115 FDA adverse-event reports reference teeth grinding (VeDDRA 128). See the species, breeds, and drugs most associated with it below.

115
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
115
Total Reports
16
Deaths
13.9%
Death Rate

Species Most Affected

Dog 68
Horse 19
Cat 19
Cattle 4
Sheep 1
Goat 1
Rabbit 1
Other Equids 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 11
Retriever - Labrador 6
Thoroughbred 6
Boxer (German Boxer) 6
Retriever - Golden 4
Horse (unknown) 4
Deutsche Dogge, Great Dane 3
Terrier - Yorkshire 3
Cat (unknown) 3
Arab 3

Associated Drugs

Milbemycin Oxime + Spinosad 11
Afoxolaner 7
Bedinvetmab 6
Cefovecin 5
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 5
Fluralaner Chew Tablets 5
Spinosad 4
Ceftiofur Crystalline Free Acid 4
Prednisone 4
Ivermectin + Pyrantel As Pamoate Salt 4
Maropitant Citrate 4
Oclacitinib Maleate 4
Pyrantel Pamoate;Sarolaner 4
Firocoxib 3
Milbemycin Oxime + Praziquantel 3
Trilostane 3
Frunevetmab 3
Fluoxetine 2
Carprofen 2
Cyclosporine 2

Teeth grinding Reaction Insights

115 reports name Teeth grinding; 16 recorded a death outcome (13.9% of reported events, not a population-level mortality rate). VeDDRA code: 128.

By species: Dog (68 reports), Horse (19 reports), Cat (19 reports). By breed: Domestic Shorthair (11), Retriever - Labrador (6), Thoroughbred (6).

Most co-reported drugs: Milbemycin Oxime + Spinosad (11 reports), Afoxolaner (7 reports), Bedinvetmab (6 reports), Cefovecin (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.