Reaction profile

The FDA adverse-event record for eyesight trouble

62 FDA adverse-event reports reference eyesight trouble (VeDDRA 1231). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1633 of 2,481
by report volume (all reactions)
62
reports citing this reaction
17.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eyesight trouble has 62 reports now versus 58 in that prior snapshot: 4 more (6.9%).

Report change
+4
Death-coded reports
+0
Death-coded share
−1.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eyesight trouble changes

FDA AER · VeDDRA plate

Code 1231 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 62 reports
  • DEATH-ELEV 17.7%
  • MID-PACK #1633/2481
  • PHOTO-FINISH Application site ting…
  • SPECIES-DOG Dog · 54
  • DRUG-LEAD Milbemycin Oxime… · 12
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site tingling (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Eyesight trouble

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site ting… · near62Claw / hoof / nail lo… · near62Desquamation · near62Dropper, Abnormal · near62Eyesight trouble · this reac…62Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Eyesight trouble

What the FDA AER plate says about Eyesight trouble

Signature read: report volume at 62 (#1633 of 2,481) is the standout scale stamp on Eyesight trouble. Report volume sits in the middle third of the reaction corpus. 11 of 62 reports were death-coded (17.7% of named reports, not a population mortality rate). Nearest volume peer: Application site tingling (±0 reports). Lead species Dog (54). Lead co-reported drug Milbemycin Oxime + Spinosad (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 54
Cat 8

Breeds Most Affected

Chihuahua 6
Domestic Shorthair 5
Shepherd Dog - Australian 4
Retriever - Labrador 4
Terrier - Yorkshire 3
Crossbred Canine/dog 3
Shih Tzu 3
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 2
Pug 2
Shepherd (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Spinosad 8
Trilostane 4
Pyrantel Pamoate;Sarolaner 4
Afoxolaner 4
Ivermectin 3
Rabies Vaccine 3
Oclacitinib Maleate 3
Prednisone 3
Bedinvetmab 3
Selamectin 2
Bordetella Vaccine 2
Nitenpyram 2
Sarolaner 2
Selamectin;Sarolaner 2
Moxidectin 2
Maropitant Citrate 2
Lotilaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Omeprazole 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Eyesight trouble, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (62 here).

Similar death-coded share

Nearest other reactions by death-coded share (17.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eyesight trouble (#1633 of 2,481 by report volume); death-coded 17.7%. PlainBreed reaction plate · report volume stamp 62 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →