Reaction profile

The FDA adverse-event record for eyesight trouble

57 FDA adverse-event reports reference eyesight trouble (VeDDRA 1231). See the species, breeds, and drugs most associated with it below.

57
reports citing this reaction
17.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
57
Total Reports
10
Deaths
17.5%
Death Rate

Species Most Affected

Dog 49
Cat 8

Breeds Most Affected

Chihuahua 5
Domestic Shorthair 5
Shepherd Dog - Australian 3
Retriever - Labrador 3
Terrier - Yorkshire 3
Crossbred Canine/dog 3
Shih Tzu 3
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 2
Pug 2
Shepherd (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 12
Spinosad 8
Pyrantel Pamoate;Sarolaner 4
Afoxolaner 4
Ivermectin 3
Rabies Vaccine 3
Oclacitinib Maleate 3
Trilostane 3
Prednisone 3
Selamectin 2
Bordetella Vaccine 2
Nitenpyram 2
Sarolaner 2
Selamectin;Sarolaner 2
Moxidectin 2
Maropitant Citrate 2
Lotilaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 1
Fluoxetine Hydrochloride 1

Eyesight trouble Reaction Insights

57 reports name Eyesight trouble; 10 recorded a death outcome (17.5% of reported events, not a population-level mortality rate). VeDDRA code: 1231.

By species: Dog (49 reports), Cat (8 reports). By breed: Chihuahua (5), Domestic Shorthair (5), Shepherd Dog - Australian (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (12 reports), Spinosad (8 reports), Pyrantel Pamoate;Sarolaner (4 reports), Afoxolaner (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.