Reaction profile

The FDA adverse-event record for ineffective, estrus synchroniz

247 FDA adverse-event reports reference ineffective, estrus synchroniz (VeDDRA 99104). See the species, breeds, and drugs most associated with it below.

247
reports citing this reaction
0.0%
death-coded share
Cattle
most-affected species
Dinoprost Tromethamine
most-associated drug
Verify with FDA CVM →
247
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Cattle 224
Pig 12
Sheep 4
Horse 2
Goat 2
Other Deer 1
Other Porcine 1
Other 1

Breeds Most Affected

Aberdeen Angus 47
Mixed (Cattle) 38
Cattle (other) 37
Cattle (unknown) 29
Holstein-Friesian also known as Holstein 26
Cattle (unspecified) 17
Hereford cattle 10
Crossbred Porcine/Pig 4
Pig (unknown) 4
Brangus 3

Associated Drugs

Dinoprost Tromethamine 133
Progesterone 93
Cloprostenol 263 Inj Cattle 23
Cloprostenol Sodium 18
Gonadorelin Diacetate Tetrahydrate 16
Gonadorelin Hydrochloride 9
Gnrh 6
Altrenogest Oily Solution 6
Altrenogest 4
Gonadorelin Injectable 4
Estrumate 4
Chorionic Gonadotropin, Serum Gonadotropin 3
Melengestrol Acetate 3
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 3
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 3
Dinoprost 2
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 2
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 2
Pregnyl/Gestyl 200/400 2
Altrenogest Oily Pig Spray 2

INEFFECTIVE, ESTRUS SYNCHRONIZ Reaction Insights

247 reports name INEFFECTIVE, ESTRUS SYNCHRONIZ; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99104.

By species: Cattle (224 reports), Pig (12 reports), Sheep (4 reports). By breed: Aberdeen Angus (47), Mixed (Cattle) (38), Cattle (other) (37).

Most co-reported drugs: Dinoprost Tromethamine (133 reports), Progesterone (93 reports), Cloprostenol 263 Inj Cattle (23 reports), Cloprostenol Sodium (18 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.