Reaction profile

The FDA adverse-event record for tenesmus

359 FDA adverse-event reports reference tenesmus (VeDDRA 273). See the species, breeds, and drugs most associated with it below.

359
reports citing this reaction
13.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
359
Total Reports
48
Deaths
13.4%
Death Rate

Species Most Affected

Dog 323
Cat 29
Cattle 5
Horse 2

Breeds Most Affected

Crossbred Canine/dog 31
Retriever - Labrador 27
Dachshund (unspecified) 15
Shepherd Dog - German 15
Retriever - Golden 14
Domestic Shorthair 11
Shih Tzu 10
Pit Bull 10
Chihuahua 9
Spaniel - Cocker American 9

Associated Drugs

Milbemycin Oxime + Spinosad 31
Carprofen 25
Ivermectin + Pyrantel As Pamoate Salt 20
Afoxolaner 17
Spinosad 15
Cyclosporine A 15
Cyclosporine 14
Meloxicam 13
Selamectin 12
Fluralaner Chew Tablets 12
Imidacloprid + Moxidectin 11
Maropitant Citrate 11
Moxidectin 10
Deracoxib 10
Tramadol 10
Milbemycin Oxime + Praziquantel 8
Lufenuron + Milbemycin Oxime 7
Cefovecin 7
Gabapentin 7
Grapiprant 7

Tenesmus Reaction Insights

359 reports name Tenesmus; 48 recorded a death outcome (13.4% of reported events, not a population-level mortality rate). VeDDRA code: 273.

By species: Dog (323 reports), Cat (29 reports), Cattle (5 reports). By breed: Crossbred Canine/dog (31), Retriever - Labrador (27), Dachshund (unspecified) (15).

Most co-reported drugs: Milbemycin Oxime + Spinosad (31 reports), Carprofen (25 reports), Ivermectin + Pyrantel As Pamoate Salt (20 reports), Afoxolaner (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.