Reaction profile

The FDA adverse-event record for bilirubinuria

838 FDA reports name bilirubinuria, a high-volume reaction in the CVM extract (VeDDRA 2175). Plate stamps and neighbourhood peers follow.

#447 of 2,481
by report volume (all reactions)
838
reports citing this reaction
26.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Bilirubinuria has 838 reports now versus 820 in that prior snapshot: 18 more (2.2%).

Report change
+18
Death-coded reports
+3
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Bilirubinuria changes

FDA AER · VeDDRA plate

Code 2175 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 838 reports
  • DEATH-HOT 26.7%
  • UPPER-Q #447/2481
  • PHOTO-FINISH Pinnal erythema
  • SPECIES-DOG Dog · 710
  • DRUG-LEAD Carprofen · 224
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Pinnal erythema (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Bilirubinuria

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (ect… · near848Injection site inflam… · near847Bilirubinuria · this reaction838Pinnal erythema · near837Skin hyperaemia · near837Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Bilirubinuria

Bilirubinuria: high death-coded share in the FDA AER plate

Signature read: 224 death-coded reports is a heavy tail count for Bilirubinuria in the CVM extract. Report volume is upper-third scale: 838 named reports in the openFDA extract. Death-coded share is upper-third: 224 of 838 reports (26.7% of named reports). Nearest volume peer: Pinnal erythema (±1 reports). Lead species Dog (710). Lead co-reported drug Carprofen (224).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 710
Cat 127
Human 1

Breeds Most Affected

Retriever - Labrador 155
Domestic Shorthair 68
Crossbred Canine/dog 64
Retriever - Golden 28
Shepherd Dog - German 27
Domestic (unspecified) 20
Chihuahua 20
Collie - Border 17
Pug 15
Shepherd Dog - Australian 14

Associated Drugs

Carprofen 224
Maropitant Citrate 112
Milbemycin Oxime + Spinosad 49
Moxidectin 43
Famotidine 43
Fluralaner Chew Tablets 43
Afoxolaner 39
Meloxicam 36
Oclacitinib Maleate 35
Cefovecin 34
Gabapentin 34
Metronidazole 31
Enrofloxacin 27
Deracoxib 25
Doxycycline 25
Ivermectin + Pyrantel As Pamoate Salt 25
Bedinvetmab 25
Mirtazapine 23
Buprenorphine 23
Fluralaner 13.64% 12-Week Chew 22

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Bilirubinuria, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (26.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Bilirubinuria (#447 of 2,481 by report volume); death-coded 26.7%. PlainBreed reaction plate · death-coded report count stamp 224 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →