Reaction profile

The FDA adverse-event record for bilirubinuria

793 FDA adverse-event reports reference bilirubinuria (VeDDRA 2175). See the species, breeds, and drugs most associated with it below.

793
reports citing this reaction
26.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
793
Total Reports
208
Deaths
26.2%
Death Rate

Species Most Affected

Dog 685
Cat 108

Breeds Most Affected

Retriever - Labrador 152
Crossbred Canine/dog 64
Domestic Shorthair 54
Retriever - Golden 28
Shepherd Dog - German 27
Domestic (unspecified) 20
Chihuahua 19
Collie - Border 17
Boxer (German Boxer) 14
Pit Bull 14

Associated Drugs

Carprofen 220
Maropitant Citrate 93
Milbemycin Oxime + Spinosad 49
Famotidine 43
Fluralaner Chew Tablets 43
Moxidectin 41
Afoxolaner 38
Oclacitinib Maleate 35
Meloxicam 34
Cefovecin 30
Metronidazole 28
Deracoxib 25
Enrofloxacin 24
Gabapentin 23
Ivermectin + Pyrantel As Pamoate Salt 23
Spinosad 21
Sam-E, Silybin, Vitamin E, Zinc 21
Fluralaner 13.64% 12-Week Chew 21
Bedinvetmab 21
Doxycycline 20

Bilirubinuria Reaction Insights

793 reports name Bilirubinuria; 208 recorded a death outcome (26.2% of reported events, not a population-level mortality rate). VeDDRA code: 2175.

By species: Dog (685 reports), Cat (108 reports). By breed: Retriever - Labrador (152), Crossbred Canine/dog (64), Domestic Shorthair (54).

Most co-reported drugs: Carprofen (220 reports), Maropitant Citrate (93 reports), Milbemycin Oxime + Spinosad (49 reports), Famotidine (43 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.