Reaction profile

The FDA adverse-event record for lack of efficacy (ectoparasite) - ear mite

823 FDA adverse-event reports reference lack of efficacy (ectoparasite) - ear mite (VeDDRA 2791). See the species, breeds, and drugs most associated with it below.

823
reports citing this reaction
0.4%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
823
Total Reports
3
Deaths
0.4%
Death Rate

Species Most Affected

Cat 621
Dog 193
Ferret 5
Rabbit 2
Other 1
Unknown 1

Breeds Most Affected

Domestic Shorthair 228
Cat (unknown) 117
Domestic (unspecified) 69
Cat (other) 57
Domestic Longhair 49
Dog (unknown) 30
Domestic Mediumhair 26
Siamese 23
Crossbred Canine/dog 20
Terrier - Yorkshire 17

Associated Drugs

Selamectin 514
Milbemycin Oxime 77
Selamectin;Sarolaner 66
Imidacloprid + Moxidectin 65
Eprinomectin + Esafoxolaner + Praziquantel 42
Ivermectin 25
Fluralaner/Moxidectin Spot-On 15
Milbemycin Oxime Solution 9
Fluralaner Spot-On Solution 9
Afoxolaner 7
Ear Cleaner (Unknown) 6
Nitenpyram 5
Pyrantel Pamoate;Sarolaner 5
Thiabendazole, Dexamethasone, Neomycin Sulfate 4
Lotilaner 4
Di-N-Propyl Isocinchomeronate; N-Octyl Bicycloheptene Dicarboximide; Piperonyl B 3
Anesthetic (Unknown) 3
Fluralaner 13.64% 12-Week Chew 3
Milbemycin 2
Amoxicillin 2

Lack of efficacy (ectoparasite) - ear mite Reaction Insights

823 reports name Lack of efficacy (ectoparasite) - ear mite; 3 recorded a death outcome (0.4% of reported events, not a population-level mortality rate). VeDDRA code: 2791.

By species: Cat (621 reports), Dog (193 reports), Ferret (5 reports). By breed: Domestic Shorthair (228), Cat (unknown) (117), Domestic (unspecified) (69).

Most co-reported drugs: Selamectin (514 reports), Milbemycin Oxime (77 reports), Selamectin;Sarolaner (66 reports), Imidacloprid + Moxidectin (65 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.