Reaction profile

The FDA adverse-event record for epilepsy

201 FDA adverse-event reports reference epilepsy (VeDDRA 647). See the species, breeds, and drugs most associated with it below.

201
reports citing this reaction
9.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
201
Total Reports
18
Deaths
9.0%
Death Rate

Species Most Affected

Dog 200
Cat 1

Breeds Most Affected

Retriever - Labrador 24
Crossbred Canine/dog 22
Dog (unknown) 13
Retriever - Golden 12
Shepherd Dog - Australian 8
Shepherd Dog - German 8
Chihuahua 7
Boxer (German Boxer) 5
Siberian Husky 4
Collie - Border 4

Associated Drugs

Milbemycin Oxime + Spinosad 32
Fluralaner Chew Tablets 29
Fluralaner 13.64% 12-Week Chew 29
Afoxolaner 24
Pyrantel Pamoate;Sarolaner 19
Ivermectin + Pyrantel As Pamoate Salt 14
Sarolaner 13
Spinosad 9
Milbemycin Oxime + Praziquantel 9
Levetiracetam 8
Ivermectin 7
Moxidectin 7
Lotilaner 6
Phenobarbital 5
Oclacitinib Maleate 5
Imidacloprid + Moxidectin 4
Gabapentin 4
Diazepam 3
Carprofen 3
Selamectin 3

Epilepsy Reaction Insights

201 reports name Epilepsy; 18 recorded a death outcome (9.0% of reported events, not a population-level mortality rate). VeDDRA code: 647.

By species: Dog (200 reports), Cat (1 reports). By breed: Retriever - Labrador (24), Crossbred Canine/dog (22), Dog (unknown) (13).

Most co-reported drugs: Milbemycin Oxime + Spinosad (32 reports), Fluralaner Chew Tablets (29 reports), Fluralaner 13.64% 12-Week Chew (29 reports), Afoxolaner (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.