Reaction profile

The FDA adverse-event record for epilepsy

209 FDA adverse-event reports reference epilepsy (VeDDRA 647). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1011 of 2,481
by report volume (all reactions)
209
reports citing this reaction
9.1%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Epilepsy has 209 reports now versus 206 in that prior snapshot: 3 more (1.5%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Epilepsy changes

FDA AER · VeDDRA plate

Code 647 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 209 reports
  • DEATH-PAR 9.1%
  • MID-PACK #1011/2481
  • PHOTO-FINISH Drug prescribing error
  • SPECIES-DOG Dog · 208
  • DRUG-LEAD Milbemycin Oxime… · 32
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drug prescribing error (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Epilepsy

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Drug prescribing error · near209Epilepsy · this reaction209Epileptic seizure · near209Puncture wound · near209Application site hair… · near208Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Epilepsy

What the FDA AER plate says about Epilepsy

Signature read: death-coded share at 9.1% is the most distinctive outcome stamp on Epilepsy. Report volume sits in the middle third of the reaction corpus. 19 of 209 reports were death-coded (9.1% of named reports, not a population mortality rate). Nearest volume peer: Drug prescribing error (±0 reports). Lead species Dog (208). Lead co-reported drug Milbemycin Oxime + Spinosad (32).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 208
Cat 1

Breeds Most Affected

Crossbred Canine/dog 25
Retriever - Labrador 24
Dog (unknown) 13
Retriever - Golden 12
Chihuahua 9
Shepherd Dog - Australian 8
Shepherd Dog - German 8
Boxer (German Boxer) 5
Siberian Husky 4
Collie - Border 4

Associated Drugs

Milbemycin Oxime + Spinosad 32
Fluralaner 13.64% 12-Week Chew 30
Fluralaner Chew Tablets 29
Afoxolaner 24
Pyrantel Pamoate;Sarolaner 20
Ivermectin + Pyrantel As Pamoate Salt 14
Sarolaner 13
Milbemycin Oxime + Praziquantel 10
Spinosad 9
Levetiracetam 9
Moxidectin 8
Ivermectin 7
Oclacitinib Maleate 6
Lotilaner 6
Phenobarbital 5
Gabapentin 5
Imidacloprid + Moxidectin 4
Carprofen 4
Bedinvetmab 4
Diazepam 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Epilepsy, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (9.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Epilepsy (#1011 of 2,481 by report volume); death-coded 9.1%. PlainBreed reaction plate · death-coded share stamp 9.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →