Reaction profile

The FDA adverse-event record for residues in milk

372 FDA adverse-event reports reference residues in milk (VeDDRA 2043). See the species, breeds, and drugs most associated with it below.

372
reports citing this reaction
1.3%
death-coded share
Cattle
most-affected species
Cephapirin Sodium
most-associated drug
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372
Total Reports
5
Deaths
1.3%
Death Rate

Species Most Affected

Cattle 366
Goat 5
Horse 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 190
Cattle (other) 91
Cattle (unknown) 54
Jersey 16
Crossbred Bovine/Cattle 8
Goat (unknown) 4
Brown Swiss 3
Unknown 2
Ayrshire 1
Mixed (Cattle) 1

Associated Drugs

Cephapirin Sodium 179
Ceftiofur Hydrochloride 74
Cephapirin Benzathine 22
Cloxacillin Benzathine 16
Ceftiofur Crystalline Free Acid 14
Ampicillin Trihydrate 13
Cloxacillin Benz Intramam Dc 12
Ceftiofur 10
Tulathromycin 9
Dihydrostreptomycin, Penicillin G Procaine 6
Ceftiofur Sodium 5
Hetacillin Potassium 5
Pirlimycin Hydrochloride 4
Doramectin 2
Penicillin G Procaine 2
Pirlimycin 2
Eprinomectin 2
Ampicillin 2
Dinoprost Tromethamine 1
Oxytetracycline 1

Residues in milk Reaction Insights

372 reports name Residues in milk; 5 recorded a death outcome (1.3% of reported events, not a population-level mortality rate). VeDDRA code: 2043.

By species: Cattle (366 reports), Goat (5 reports), Horse (1 reports). By breed: Holstein-Friesian also known as Holstein (190), Cattle (other) (91), Cattle (unknown) (54).

Most co-reported drugs: Cephapirin Sodium (179 reports), Ceftiofur Hydrochloride (74 reports), Cephapirin Benzathine (22 reports), Cloxacillin Benzathine (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.