Reaction profile
The FDA adverse-event record for abnormal pupil light reflex
953 FDA reports name abnormal pupil light reflex, a high-volume reaction in the CVM extract (VeDDRA 1097). Plate stamps and neighbourhood peers follow.
- #407 of 2,481
- by report volume (all reactions)
- 953
- reports citing this reaction
- 23.0%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal pupil light reflex has 953 reports now versus 929 in that prior snapshot: 24 more (2.6%).
- Report change
- +24
- Death-coded reports
- +5
- Death-coded share
- −0.1 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Abnormal pupil light reflex changesFDA AER · VeDDRA plate
Code 1097 VOL-MID
VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-MID 953 reports
- DEATH-HOT 23.0%
- UPPER-Q #407/2481
- PHOTO-FINISH Eye irritation
- SPECIES-DOG Dog · 664
- DRUG-LEAD Milbemycin Oxime… · 119
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Eye irritation (±2 reports)
Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.
High-volume neighbourhood around Abnormal pupil light reflex
Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.
What the FDA AER plate says about Abnormal pupil light reflex
Signature read: 219 death-coded reports is a heavy tail count for Abnormal pupil light reflex in the CVM extract. Report volume is upper-third scale: 953 named reports in the openFDA extract. 219 of 953 reports were death-coded (23.0% of named reports, not a population mortality rate). Nearest volume peer: Eye irritation (±2 reports). Lead species Dog (664). Lead co-reported drug Milbemycin Oxime + Spinosad (119).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Abnormal pupil light reflex, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (953 here).
Similar death-coded share
Nearest other reactions by death-coded share (23.0% here), distinct from the volume row.
What to do with this reaction
- Compare Abnormal pupil light reflex's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →