Drug profile

The FDA adverse-event record for Vetmedin

158 FDA reports name Vetmedin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#611 of 2,679
by report volume (all drugs)
158
adverse-event reports
31.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Vetmedin ranks #607 of 2679 by total reports (158) and #117 of 1130 by death-coded share (31.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#607
This drug, reports of 2679
#117
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vetmedin has 158 reports now versus 153 in that prior snapshot: 5 more (3.3%).

Report change
+5
Death-coded reports
+2
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vetmedin changes

Signature read: death-coded report count at 49 is the most distinctive stamp on Vetmedin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
158
Total Reports
49
Deaths Reported
31.0%
Death-coded share of reports

Active Ingredients

Vetmedin

Administration Routes

OralUnknownRectal

Species Affected

Dog 152
Cat 6

Most Affected Breeds

Chihuahua 21
Terrier - Yorkshire 9
Shih Tzu 7
Spaniel (unspecified) 7
Terrier (unspecified) 6
Spaniel - King Charles Cavalier 6
Beagle 5
Retriever - Labrador 5
Retriever - Golden 4
Dachshund - Miniature 4

Most Reported Reactions

Death by euthanasia 28
Vomiting 22
Seizure NOS 22
Death 21
Panting 18
Lethargy (see also Central nervous system depression in Neurological) 18
Diarrhoea 16
Ataxia 14
Cough 12
Not eating 12
Weight loss 10
Limb weakness 10

Outcome Breakdown

Ongoing
73 (46.2%)
Euthanized
28 (17.7%)
Recovered/Normal
24 (15.2%)
Died
21 (13.3%)
Outcome Unknown
12 (7.6%)

Vetmedin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Vetmedin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vetmedin (#611 of 2,679 by report volume); death-coded 31.0%. PlainBreed drug row · death-coded report count stamp 49 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →