Drug profile

The FDA adverse-event record for Metoclopramide

612 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Metoclopramide. See the species affected, top reactions, and outcomes below.

612
adverse-event reports
31.9%
death-coded share
Dog
most-reported species
192
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
612
Total Reports
195
Deaths Reported
31.9%
Death Rate

Active Ingredients

Metoclopramide

Administration Routes

UnknownOralIntravenousSubcutaneousParenteralIntramuscularTopicalOther

Species Affected

Dog 538
Cat 70
Rabbit 3
Guinea Pig 1

Most Affected Breeds

Retriever - Labrador 90
Domestic Shorthair 39
Crossbred Canine/dog 24
Bulldog 18
Retriever - Golden 18
Terrier - Yorkshire 15
Shepherd Dog - German 15
Boxer (German Boxer) 14
Dog (unknown) 12
Terrier - Bull - American Pit 12

Most Reported Reactions

Vomiting 192
Lethargy (see also Central nervous system depression in 'Neurological') 123
Diarrhoea 118
Death by euthanasia 113
Anorexia 107
Other abnormal test result NOS 106
Death 78
Elevated total bilirubin 75
Weight loss 71
Elevated alanine aminotransferase (ALT) 71
Emesis 66
Leucocytosis NOS 66

Outcome Breakdown

Ongoing
172 (28.0%)
Recovered/Normal
144 (23.5%)
Euthanized
111 (18.1%)
Outcome Unknown
96 (15.6%)
Died
84 (13.7%)
Recovered with Sequela
7 (1.1%)

Metoclopramide Adverse Event Insights

612 reports name Metoclopramide; 195 recorded a death outcome (31.9% of reported events, not a population-level mortality rate). Active ingredient: Metoclopramide. Administration routes: Unknown, Oral, Intravenous, Subcutaneous.

By species: Dog (538 reports), Cat (70 reports), Rabbit (3 reports). By breed: Retriever - Labrador (90), Domestic Shorthair (39), Crossbred Canine/dog (24).

Leading clinical signs: Vomiting (192), Lethargy (see also Central nervous system depression in 'Neurological') (123), Diarrhoea (118), Death by euthanasia (113). Outcome, 614 coded reports: Ongoing leads at 28.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.