Drug profile

The FDA adverse-event record for Atropine

672 FDA reports name Atropine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#244 of 2,679
by report volume (all drugs)
672
adverse-event reports
30.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Atropine ranks #244 of 2679 by total reports (672) and #121 of 1130 by death-coded share (30.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#244
This drug, reports of 2679
#121
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Atropine has 672 reports now versus 665 in that prior snapshot: 7 more (1.1%).

Report change
+7
Death-coded reports
+1
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Atropine changes

Signature read: death-coded report count at 206 is the most distinctive stamp on Atropine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
672
Total Reports
206
Deaths Reported
30.7%
Death-coded share of reports

Active Ingredients

Atropine

Administration Routes

UnknownSubcutaneousIntravenousIntramuscularOphthalmicOtherParenteralIntracardiacRespiratory (Inhalation)Endotracheal

Species Affected

Dog 505
Cat 156
Horse 6
Unknown 1
Other Mammals 1
Rat 1
Ferret 1
Monkey 1

Most Affected Breeds

Domestic Shorthair 99
Retriever - Labrador 61
Dog (unknown) 38
Chihuahua 27
Terrier - Bull - American Pit 20
Shih Tzu 19
Terrier - Yorkshire 19
Retriever - Golden 17
Crossbred Canine/dog 16
Maltese 12

Most Reported Reactions

Death 152
Vomiting 108
Cardiac arrest 92
Lethargy (see also Central nervous system depression in 'Neurological') 87
Bradycardia 85
Other abnormal test result NOS 55
Anorexia 51
Lack of efficacy - NOS 50
Death by euthanasia 47
Tachycardia 46
Hypothermia 45
Seizure NOS 45

Outcome Breakdown

Recovered/Normal
223 (32.9%)
Ongoing
167 (24.7%)
Died
161 (23.8%)
Outcome Unknown
73 (10.8%)
Euthanized
46 (6.8%)
Recovered with Sequela
7 (1.0%)

Atropine: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Atropine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (672 here).

Similar death-coded share

Nearest other drugs by death-coded share (30.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Atropine (#244 of 2,679 by report volume); death-coded 30.7%. PlainBreed drug row · death-coded report count stamp 206 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →