Drug profile

The FDA adverse-event record for Unknown Fluids

56 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Unknown Fluids. Species, reactions, and outcomes follow.

#1053 of 2,679
by report volume (all drugs)
56
adverse-event reports
16.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Unknown Fluids ranks #1044 of 2679 by total reports (56) and #336 of 1130 by death-coded share (16.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1044
This drug, reports of 2679
#336
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unknown Fluids has 56 reports now versus 56 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unknown Fluids changes

Signature read: death-coded report count at 9 is the most distinctive stamp on Unknown Fluids's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
56
Total Reports
9
Deaths Reported
16.1%
Death-coded share of reports

Active Ingredients

Unknown Fluids

Administration Routes

UnknownIntravenousSubcutaneous

Species Affected

Dog 37
Cat 18
Sheep 1

Most Affected Breeds

Domestic Shorthair 10
Terrier - Rat 4
Crossbred Canine/dog 4
Shih Tzu 3
Chihuahua 3
Shepherd Dog - Australian 2
Domestic Longhair 2
Cat (unknown) 2
Retriever - Golden 2
Retriever - Labrador 2

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 14
Vomiting 12
Ataxia 11
Lethargy (see also Central nervous system depression in Neurological) 11
Decreased appetite 9
Dehydration 8
Anorexia 7
Inappropriate urination 7
Head shake - ear disorder 6
Pain NOS 6
Otitis externa 6
Not eating 6

Outcome Breakdown

Ongoing
19 (33.9%)
Recovered/Normal
14 (25.0%)
Outcome Unknown
13 (23.2%)
Died
6 (10.7%)
Euthanized
3 (5.4%)
Recovered with Sequela
1 (1.8%)

Unknown Fluids Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Unknown Fluids, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unknown Fluids (#1053 of 2,679 by report volume); death-coded 16.1%. PlainBreed drug row · death-coded report count stamp 9 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →