Drug profile

The FDA adverse-event record for Anesthesia

279 FDA reports name Anesthesia, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#445 of 2,679
by report volume (all drugs)
279
adverse-event reports
16.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Anesthesia ranks #445 of 2679 by total reports (279) and #335 of 1130 by death-coded share (16.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#445
This drug, reports of 2679
#335
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Anesthesia has 279 reports now versus 273 in that prior snapshot: 6 more (2.2%).

Report change
+6
Death-coded reports
+2
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Anesthesia changes

Signature read: death-coded report count at 45 is the most distinctive stamp on Anesthesia's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
279
Total Reports
45
Deaths Reported
16.1%
Death-coded share of reports

Active Ingredients

Anesthesia

Administration Routes

UnknownRespiratory (Inhalation)OtherSubcutaneousOral

Species Affected

Dog 186
Cat 92
Horse 1

Most Affected Breeds

Domestic Shorthair 50
Retriever - Labrador 24
Domestic Longhair 12
Retriever - Golden 12
Terrier - Bull - American Pit 10
Shih Tzu 9
Cat (unknown) 9
Boxer (German Boxer) 9
Chihuahua 8
Crossbred Canine/dog 8

Most Reported Reactions

Vomiting 47
Diarrhoea 28
Anorexia 27
Lethargy (see also Central nervous system depression in Neurological) 26
Lethargy (see also Central nervous system depression in 'Neurological') 25
Death 24
Death by euthanasia 20
Not eating 20
Fever 19
Elevated alanine aminotransferase (ALT) 16
Other abnormal test result NOS 15
Elevated total bilirubin 15

Outcome Breakdown

Ongoing
113 (40.5%)
Recovered/Normal
72 (25.8%)
Outcome Unknown
47 (16.8%)
Died
27 (9.7%)
Euthanized
18 (6.5%)
Recovered with Sequela
2 (0.7%)

Anesthesia: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Anesthesia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (279 here).

Similar death-coded share

Nearest other drugs by death-coded share (16.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Anesthesia (#445 of 2,679 by report volume); death-coded 16.1%. PlainBreed drug row · death-coded report count stamp 45 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →