Drug profile

The FDA adverse-event record for Firocoxib

3,597 FDA reports name Firocoxib, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#67 of 2,679
by report volume (all drugs)
3,597
adverse-event reports
16.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Firocoxib ranks #67 of 2679 by total reports (3,597) and #338 of 1130 by death-coded share (16.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#67
This drug, reports of 2679
#338
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Firocoxib has 3,597 reports now versus 3,559 in that prior snapshot: 38 more (1.1%).

Report change
+38
Death-coded reports
+2
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Firocoxib changes

Signature read: death-coded report count at 574 is the most distinctive stamp on Firocoxib's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,597
Total Reports
574
Deaths Reported
16.0%
Death-coded share of reports

Active Ingredients

Firocoxib

Administration Routes

OralUnknownIntravenousSubcutaneousIntraocularOtherIntramuscularTopical

Species Affected

Dog 2,785
Unknown 409
Horse 362
Cat 20
Human 14
Mule 3
Other 2
Donkey 2

Most Affected Breeds

Retriever - Labrador 466
Unknown 441
Crossbred Canine/dog 291
Dog (unknown) 210
Retriever - Golden 158
Shepherd Dog - German 124
Boxer (German Boxer) 104
Quarter Horse 99
Rottweiler 85
Horse (unknown) 81

Most Reported Reactions

Vomiting 880
Anorexia 459
Diarrhoea 396
Elevated blood urea nitrogen (BUN) 355
Lethargy (see also Central nervous system depression in 'Neurological') 307
Death 283
Elevated creatinine 277
Death by euthanasia 273
Elevated serum alkaline phosphatase (SAP) 227
Elevated alanine aminotransferase (ALT) 219
Other abnormal test result NOS 218
Depression 202

Outcome Breakdown

Outcome Unknown
885 (36.8%)
Recovered/Normal
575 (23.9%)
Died
398 (16.5%)
Ongoing
353 (14.7%)
Euthanized
176 (7.3%)
Recovered with Sequela
21 (0.9%)

Firocoxib: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Firocoxib, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (16.0% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Firocoxib (#67 of 2,679 by report volume); death-coded 16.0%. PlainBreed drug row · death-coded report count stamp 574 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →