Drug profile

The FDA adverse-event record for Rabies Vaccine

4,199 FDA reports name Rabies Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#54 of 2,679
by report volume (all drugs)
4,199
adverse-event reports
10.6%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Rabies Vaccine ranks #54 of 2679 by total reports (4,199) and #520 of 1130 by death-coded share (10.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#54
This drug, reports of 2679
#520
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Rabies Vaccine has 4,199 reports now versus 4,069 in that prior snapshot: 130 more (3.2%).

Report change
+130
Death-coded reports
+18
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Rabies Vaccine changes

Signature read: death-coded report count at 447 is the most distinctive stamp on Rabies Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
4,199
Total Reports
447
Deaths Reported
10.6%
Death-coded share of reports

Active Ingredients

Rabies Vaccine

Administration Routes

UnknownSubcutaneousParenteralOralIntramuscularOtherTopicalIntrauterineSubconjunctivalTransdermal

Species Affected

Dog 3,149
Cat 1,044
Horse 3
Unknown 2
Pig 1

Most Affected Breeds

Domestic Shorthair 766
Retriever - Labrador 363
Chihuahua 186
Crossbred Canine/dog 152
Retriever - Golden 136
Shepherd Dog - German 131
Shih Tzu 119
Terrier - Yorkshire 118
Pit Bull 116
Shepherd Dog - Australian 91

Most Reported Reactions

Vomiting 1,139
Lethargy (see also Central nervous system depression in 'Neurological') 673
Emesis 459
Diarrhoea 434
Lethargy (see also Central nervous system depression in Neurological) 354
Other abnormal test result NOS 327
Not eating 298
Anorexia 271
Behavioural disorder NOS 244
Death 237
Seizure NOS 214
Weight loss 213

Outcome Breakdown

Recovered/Normal
1,705 (40.6%)
Outcome Unknown
1,076 (25.6%)
Ongoing
853 (20.3%)
Died
272 (6.5%)
Euthanized
175 (4.2%)
Recovered with Sequela
118 (2.8%)

Rabies Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Rabies Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (10.6% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Rabies Vaccine (#54 of 2,679 by report volume); death-coded 10.6%. PlainBreed drug row · death-coded report count stamp 447 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →