Drug profile

The FDA adverse-event record for Rabies Vaccine

3,902 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Rabies Vaccine. See the species affected, top reactions, and outcomes below.

3,902
adverse-event reports
10.5%
death-coded share
Dog
most-reported species
1,056
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,902
Total Reports
411
Deaths Reported
10.5%
Death Rate

Active Ingredients

Rabies Vaccine

Administration Routes

UnknownSubcutaneousParenteralOralIntramuscularOtherTopicalIntrauterineSubconjunctivalTransdermal

Species Affected

Dog 2,941
Cat 955
Horse 3
Unknown 2
Pig 1

Most Affected Breeds

Domestic Shorthair 702
Retriever - Labrador 337
Chihuahua 181
Crossbred Canine/dog 138
Retriever - Golden 126
Shepherd Dog - German 123
Pit Bull 113
Shih Tzu 111
Terrier - Yorkshire 105
Shepherd Dog - Australian 81

Most Reported Reactions

Vomiting 1,056
Lethargy (see also Central nervous system depression in 'Neurological') 673
Emesis 458
Diarrhoea 395
Other abnormal test result NOS 289
Lethargy (see also Central nervous system depression in Neurological) 275
Not eating 261
Anorexia 260
Behavioural disorder NOS 231
Death 219
Seizure NOS 202
Weight loss 194

Outcome Breakdown

Recovered/Normal
1,618 (41.5%)
Outcome Unknown
1,006 (25.8%)
Ongoing
748 (19.2%)
Died
253 (6.5%)
Euthanized
158 (4.1%)
Recovered with Sequela
118 (3.0%)

Rabies Vaccine Adverse Event Insights

3,902 reports name Rabies Vaccine; 411 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). Active ingredient: Rabies Vaccine. Administration routes: Unknown, Subcutaneous, Parenteral, Oral.

By species: Dog (2,941 reports), Cat (955 reports), Horse (3 reports). By breed: Domestic Shorthair (702), Retriever - Labrador (337), Chihuahua (181).

Leading clinical signs: Vomiting (1,056), Lethargy (see also Central nervous system depression in 'Neurological') (673), Emesis (458), Diarrhoea (395). Outcome, 3,901 coded reports: Recovered/Normal leads at 41.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.