Drug profile

The FDA adverse-event record for Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg

4,379 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg. See the species affected, top reactions, and outcomes below.

4,379
adverse-event reports
0.8%
death-coded share
Dog
most-reported species
1,711
Digestive tract disorder NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
4,379
Total Reports
36
Deaths Reported
0.8%
Death Rate

Active Ingredients

Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg

Administration Routes

OralUnknownSubcutaneous

Species Affected

Dog 3,953
Unknown 421
Human 2
Other Canids 1
Iguana 1
Cat 1

Most Affected Breeds

Unknown 432
Crossbred Canine/dog 370
Shih Tzu 265
Terrier - Yorkshire 251
Chihuahua 216
Dog (other) 193
Dachshund (unspecified) 165
Maltese 147
Schnauzer - Miniature 127
Dog (unknown) 120

Most Reported Reactions

Digestive tract disorder NOS 1,711
Vomiting 1,053
Lack of efficacy (endoparasite) - hookworm 881
INEFFECTIVE, HEARTWORM LARVAE 538
INEFFECTIVE, ASCARIDS NOS 532
Cardiac disorder NOS 528
Diarrhoea 432
Lethargy (see also Central nervous system depression in 'Neurological') 423
Lack of efficacy - NOS 290
Tablets, Abnormal 222
Lack of efficacy (protozoa) - Coccidia 167
Behavioural disorder NOS 113

Outcome Breakdown

Outcome Unknown
2,242 (56.5%)
Recovered/Normal
1,168 (29.4%)
Recovered with Sequela
319 (8.0%)
Ongoing
205 (5.2%)
Died
26 (0.7%)
Euthanized
11 (0.3%)

Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg Adverse Event Insights

4,379 reports name Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg; 36 recorded a death outcome (0.8% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg. Administration routes: Oral, Unknown, Subcutaneous.

By species: Dog (3,953 reports), Unknown (421 reports), Human (2 reports). By breed: Unknown (432), Crossbred Canine/dog (370), Shih Tzu (265).

Leading clinical signs: Digestive tract disorder NOS (1,711), Vomiting (1,053), Lack of efficacy (endoparasite) - hookworm (881), INEFFECTIVE, HEARTWORM LARVAE (538). Outcome, 3,971 coded reports: Outcome Unknown leads at 56.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.