Drug profile

The FDA adverse-event record for Firocoxib 227 Mg

169 FDA reports name Firocoxib 227 Mg, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#585 of 2,679
by report volume (all drugs)
169
adverse-event reports
10.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Firocoxib 227 Mg ranks #582 of 2679 by total reports (169) and #519 of 1130 by death-coded share (10.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#582
This drug, reports of 2679
#519
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Firocoxib 227 Mg has 169 reports now versus 169 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Firocoxib 227 Mg changes

Signature read: 169 reports place Firocoxib 227 Mg in the upper third of FDA AER volume (#585 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
169
Total Reports
18
Deaths Reported
10.7%
Death-coded share of reports

Active Ingredients

Firocoxib 227 Mg

Administration Routes

OralUnknown

Species Affected

Dog 126
Unknown 40
Horse 2
Cat 1

Most Affected Breeds

Unknown 40
Retriever - Labrador 30
Dog (other) 21
Retriever - Golden 8
Boxer (German Boxer) 7
Rottweiler 6
Dog (unknown) 6
Shepherd Dog - German 4
Doberman Pinscher 4
Beagle 4

Most Reported Reactions

Vomiting 45
Uncoded sign 41
Elevated blood urea nitrogen (BUN) 25
Other abnormal test result NOS 25
Elevated creatinine 21
Anorexia 17
Product problem 16
Lethargy (see also Central nervous system depression in 'Neurological') 16
Elevated alanine aminotransferase (ALT) 15
Diarrhoea 11
Elevated serum alkaline phosphatase (SAP) 10
Leucocytosis NOS 9

Outcome Breakdown

Outcome Unknown
77 (58.8%)
Ongoing
19 (14.5%)
Recovered/Normal
17 (13.0%)
Died
10 (7.6%)
Euthanized
8 (6.1%)

Firocoxib 227 Mg: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Firocoxib 227 Mg, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (10.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Firocoxib 227 Mg (#585 of 2,679 by report volume); death-coded 10.7%. PlainBreed drug row · report volume stamp 169 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →