Drug profile

The FDA adverse-event record for Firocoxib 227 Mg

169 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Firocoxib 227 Mg. See the species affected, top reactions, and outcomes below.

169
adverse-event reports
10.7%
death-coded share
Dog
most-reported species
45
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
169
Total Reports
18
Deaths Reported
10.7%
Death Rate

Active Ingredients

Firocoxib 227 Mg

Administration Routes

OralUnknown

Species Affected

Dog 126
Unknown 40
Horse 2
Cat 1

Most Affected Breeds

Unknown 40
Retriever - Labrador 30
Dog (other) 21
Retriever - Golden 8
Boxer (German Boxer) 7
Dog (unknown) 6
Rottweiler 6
Shepherd Dog - German 4
Doberman Pinscher 4
Beagle 4

Most Reported Reactions

Vomiting 45
Uncoded sign 41
Elevated blood urea nitrogen (BUN) 25
Other abnormal test result NOS 25
Elevated creatinine 21
Anorexia 17
Product problem 16
Lethargy (see also Central nervous system depression in 'Neurological') 16
Elevated alanine aminotransferase (ALT) 15
Diarrhoea 11
Elevated serum alkaline phosphatase (SAP) 10
Leucocytosis NOS 9

Outcome Breakdown

Outcome Unknown
77 (58.8%)
Ongoing
19 (14.5%)
Recovered/Normal
17 (13.0%)
Died
10 (7.6%)
Euthanized
8 (6.1%)

Firocoxib 227 Mg Adverse Event Insights

169 reports name Firocoxib 227 Mg; 18 recorded a death outcome (10.7% of reported events, not a population-level mortality rate). Active ingredient: Firocoxib 227 Mg. Administration routes: Oral, Unknown.

By species: Dog (126 reports), Unknown (40 reports), Horse (2 reports). By breed: Unknown (40), Retriever - Labrador (30), Dog (other) (21).

Leading clinical signs: Vomiting (45), Uncoded sign (41), Elevated blood urea nitrogen (BUN) (25), Other abnormal test result NOS (25). Outcome, 131 coded reports: Outcome Unknown leads at 58.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.