Drug profile

The FDA adverse-event record for Pyrantel Pamoate/ Praziquantel

56 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Pyrantel Pamoate/ Praziquantel. See the species affected, top reactions, and outcomes below.

56
adverse-event reports
5.4%
death-coded share
Dog
most-reported species
29
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
56
Total Reports
3
Deaths Reported
5.4%
Death Rate

Active Ingredients

Pyrantel Pamoate/ Praziquantel

Administration Routes

OralUnknown

Species Affected

Dog 51
Unknown 3
Cat 2

Most Affected Breeds

Dog (unknown) 7
Retriever - Labrador 6
Terrier - Yorkshire 5
Shih Tzu 3
Unknown 3
Maltese 2
Schnauzer - Miniature 2
Retriever - Golden 2
Spitz - German Pomeranian 2
Crossbred Canine/dog 2

Most Reported Reactions

Vomiting 29
Lack of efficacy (endoparasite) - tapeworm 9
Overdose 6
Bloody diarrhoea 5
Lethargy (see also Central nervous system depression in 'Neurological') 5
Diarrhoea 5
Loose stool 5
Lack of efficacy - NOS 3
Lack of efficacy (endoparasite) - hookworm 2
INEFFECTIVE, ASCARIDS NOS 2
Panting 2
Abdominal pain 2

Outcome Breakdown

Recovered/Normal
29 (54.7%)
Outcome Unknown
21 (39.6%)
Died
2 (3.8%)
Euthanized
1 (1.9%)

Pyrantel Pamoate/ Praziquantel Adverse Event Insights

56 reports name Pyrantel Pamoate/ Praziquantel; 3 recorded a death outcome (5.4% of reported events, not a population-level mortality rate). Active ingredient: Pyrantel Pamoate/ Praziquantel. Administration routes: Oral, Unknown.

By species: Dog (51 reports), Unknown (3 reports), Cat (2 reports). By breed: Dog (unknown) (7), Retriever - Labrador (6), Terrier - Yorkshire (5).

Leading clinical signs: Vomiting (29), Lack of efficacy (endoparasite) - tapeworm (9), Overdose (6), Bloody diarrhoea (5). Outcome, 53 coded reports: Recovered/Normal leads at 54.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.