Drug profile

The FDA adverse-event record for Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract

344 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract. See the species affected, top reactions, and outcomes below.

344
adverse-event reports
4.7%
death-coded share
Dog
most-reported species
185
Lack of efficacy (bacteria) - Borrelia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
344
Total Reports
16
Deaths Reported
4.7%
Death Rate

Active Ingredients

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract

Administration Routes

SubcutaneousParenteralUnknownOralOther

Species Affected

Dog 344

Most Affected Breeds

Retriever - Labrador 64
Retriever - Golden 30
Mountain Dog - Bernese 17
Shepherd Dog - Australian 14
Shepherd Dog - German 12
Terrier - Yorkshire 11
Beagle 10
Siberian Husky 10
Crossbred Canine/dog 10
Shih Tzu 9

Most Reported Reactions

Lack of efficacy (bacteria) - Borrelia 185
Lack of efficacy (ectoparasite) - tick NOS 78
Other abnormal test result NOS 58
Vomiting 34
Partial lack of efficacy 33
Lethargy (see also Central nervous system depression in 'Neurological') 20
Diarrhoea 19
Lack of efficacy (bacteria) - Anaplasma 16
Lethargy (see also Central nervous system depression in Neurological) 15
Leucocytosis NOS 12
Death by euthanasia 12
Facial swelling (see also 'Skin') 11

Outcome Breakdown

Outcome Unknown
253 (73.5%)
Recovered/Normal
42 (12.2%)
Ongoing
33 (9.6%)
Euthanized
12 (3.5%)
Died
4 (1.2%)

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract Adverse Event Insights

344 reports name Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract; 16 recorded a death outcome (4.7% of reported events, not a population-level mortality rate). Active ingredient: Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract. Administration routes: Subcutaneous, Parenteral, Unknown, Oral.

By species: Dog (344 reports). By breed: Retriever - Labrador (64), Retriever - Golden (30), Mountain Dog - Bernese (17).

Leading clinical signs: Lack of efficacy (bacteria) - Borrelia (185), Lack of efficacy (ectoparasite) - tick NOS (78), Other abnormal test result NOS (58), Vomiting (34). Outcome, 344 coded reports: Outcome Unknown leads at 73.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.