Drug profile

The FDA adverse-event record for Ivermectin(1.55%)/Praziquantel(7.75%) Paste

781 FDA reports name Ivermectin(1.55%)/Praziquantel(7.75%) Paste, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#221 of 2,679
by report volume (all drugs)
781
adverse-event reports
2.0%
death-coded share
Horse
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Ivermectin(1.55%)/Praziquantel(7.75%) Paste ranks #220 of 2679 by total reports (781) and #981 of 1130 by death-coded share (2.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#220
This drug, reports of 2679
#981
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Ivermectin(1.55%)/Praziquantel(7.75%) Paste has 781 reports now versus 781 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Ivermectin(1.55%)/Praziquantel(7.75%) Paste changes

Signature read: 781 reports place Ivermectin(1.55%)/Praziquantel(7.75%) Paste in the upper third of FDA AER volume (#221 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
781
Total Reports
16
Deaths Reported
2.0%
Death-coded share of reports

Active Ingredients

Ivermectin(1.55%)/Praziquantel(7.75%) Paste

Administration Routes

OralUnknownOther

Species Affected

Horse 629
Unknown 94
Dog 41
Human 7
Donkey 7
Goat 2
Mule 1

Most Affected Breeds

Horse (unknown) 174
Quarter Horse 135
Unknown 125
Thoroughbred 86
Arab 37
Paint 29
Tennessee Walking Horse 17
Hanovarian 16
Warmblood - Dutch 14
Appaloosa 13

Most Reported Reactions

Swollen mouth 211
Application site swelling 181
Swollen lip (see also 'Skin') 133
Anaphylactoid reaction 126
Uncoded sign 91
Swollen tongue 73
Drooling 69
Application site erythema 55
Hypersalivation 55
Not eating 51
Colic 47
Locking Mechanism Abnormal 43

Outcome Breakdown

Outcome Unknown
395 (56.8%)
Recovered/Normal
237 (34.1%)
Ongoing
46 (6.6%)
Died
11 (1.6%)
Euthanized
5 (0.7%)
Recovered with Sequela
1 (0.1%)

Ivermectin(1.55%)/Praziquantel(7.75%) Paste: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Ivermectin(1.55%)/Praziquantel(7.75%) Paste, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Ivermectin(1.55%)/Praziquantel(7.75%) Paste's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Ivermectin(1.55%)/Praziquantel(7.75%) Paste (#221 of 2,679 by report volume); death-coded 2.0%. PlainBreed drug row · report volume stamp 781 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →