Drug profile

The FDA adverse-event record for Ceftiofur Hydrochloride

766 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ceftiofur Hydrochloride. See the species affected, top reactions, and outcomes below.

766
adverse-event reports
16.6%
death-coded share
Cattle
most-reported species
100
Residues in meat/offal - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
766
Total Reports
127
Deaths Reported
16.6%
Death Rate

Active Ingredients

Ceftiofur Hydrochloride

Administration Routes

UnknownIntramammaryIntramuscularSubcutaneousIntravenousTopicalOralIntraocularSubconjunctivalOphthalmic

Species Affected

Cattle 407
Unknown 325
Human 16
Goat 6
Horse 4
Pig 4
Dog 2
Alpaca 1
Other 1

Most Affected Breeds

Unknown 342
Holstein-Friesian also known as Holstein 174
Cattle (other) 146
Cattle (unknown) 30
Jersey 24
Mixed (Cattle) 16
Cattle (unspecified) 5
Crossbred Porcine/Pig 4
Aberdeen Angus 3
Crossbred Bovine/Cattle 2

Most Reported Reactions

Residues in meat/offal 100
Lack of efficacy (bacteria) - NOS 90
Suspension, Abnormal 75
Residues in milk 74
Lack of efficacy - NOS 74
Closure, Abnormal 68
No sign 60
Death 41
Uncoded sign 40
Product Defect, General 27
Closure, Missing 27
Containers, Leaking 23

Outcome Breakdown

Outcome Unknown
258 (59.9%)
Died
68 (15.8%)
Euthanized
60 (13.9%)
Recovered/Normal
27 (6.3%)
Ongoing
14 (3.2%)
Recovered with Sequela
4 (0.9%)

Ceftiofur Hydrochloride Adverse Event Insights

766 reports name Ceftiofur Hydrochloride; 127 recorded a death outcome (16.6% of reported events, not a population-level mortality rate). Active ingredient: Ceftiofur Hydrochloride. Administration routes: Unknown, Intramammary, Intramuscular, Subcutaneous.

By species: Cattle (407 reports), Unknown (325 reports), Human (16 reports). By breed: Unknown (342), Holstein-Friesian also known as Holstein (174), Cattle (other) (146).

Leading clinical signs: Residues in meat/offal (100), Lack of efficacy (bacteria) - NOS (90), Suspension, Abnormal (75), Residues in milk (74). Outcome, 431 coded reports: Outcome Unknown leads at 59.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.