Febantel + Praziquantel + Pyrantel Pamoate
5,093 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 5,093 |
| Reports involving death | 103 |
| Case-fatality rate (reported events) | 200.0% |
| Distinct species in reports | 7 |
| Distinct breeds in reports | 20 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 3 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Febantel + Praziquantel + Pyrantel Pamoate Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 5,093 adverse event reports referencing Febantel + Praziquantel + Pyrantel Pamoate, including 103 reports in which the animal died — a 200.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredients on file: Febantel, Praziquantel, Pyrantel Pamoate. Reported administration routes include Oral, Unknown, Topical, Other. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Febantel + Praziquantel + Pyrantel Pamoate reports are Dog (4,774 reports), Unknown (279 reports), Cat (32 reports), with Dog accounting for the largest share. Within those species, Retriever - Labrador (460), Dog (unknown) (330), Unknown (286) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Febantel + Praziquantel + Pyrantel Pamoate are Vomiting (1,880), Emesis (605), Emesis (multiple) (566), Diarrhoea (493). Of the 4,818 reports with a coded outcome, Recovered/Normal is the leading category at 55.1%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Febantel + Praziquantel + Pyrantel Pamoate.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.