Drug profile

The FDA adverse-event record for Dietary Supplement

92 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dietary Supplement. See the species affected, top reactions, and outcomes below.

92
adverse-event reports
2.2%
death-coded share
Dog
most-reported species
29
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
92
Total Reports
2
Deaths Reported
2.2%
Death Rate

Active Ingredients

Dietary Supplement

Administration Routes

UnknownOral

Species Affected

Dog 47
Cat 44
Human 1

Most Affected Breeds

Domestic Shorthair 27
Crossbred Canine/dog 7
Bulldog - French 7
Domestic Longhair 5
Retriever - Labrador 5
Cat (unknown) 4
Shepherd Dog - German 3
Dog (unknown) 3
Domestic Mediumhair 3
Mixed (Dog) 2

Most Reported Reactions

Vomiting 29
Ketosis 21
Diarrhoea 16
Hyperglycaemia 14
Polyuria 13
Polydipsia 12
Lack of efficacy - NOS 10
Weight loss 10
Lethargy (see also Central nervous system depression in Neurological) 10
Other abnormal test result NOS 9
Behavioural disorder NOS 7
Not eating 7

Outcome Breakdown

Ongoing
34 (37.0%)
Outcome Unknown
32 (34.8%)
Recovered/Normal
24 (26.1%)
Died
1 (1.1%)
Euthanized
1 (1.1%)

Dietary Supplement Adverse Event Insights

92 reports name Dietary Supplement; 2 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). Active ingredient: Dietary Supplement. Administration routes: Unknown, Oral.

By species: Dog (47 reports), Cat (44 reports), Human (1 reports). By breed: Domestic Shorthair (27), Crossbred Canine/dog (7), Bulldog - French (7).

Leading clinical signs: Vomiting (29), Ketosis (21), Diarrhoea (16), Hyperglycaemia (14). Outcome, 92 coded reports: Ongoing leads at 37.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.