Doxycycline

3,706 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

3,706

Total Reports

530

Deaths Reported

1430.0%

Death Rate

Active Ingredients

Doxycycline

Administration Routes

OralUnknownIntravenousTopicalSubcutaneousPeriodontalIntramuscularAuricular (Otic)OphthalmicParenteral

Species Affected

Dog 3,469

Cat 207

Unknown 15

Horse 14

Human 1

Most Affected Breeds

Retriever - Labrador 470

Crossbred Canine/dog 193

Shepherd Dog - German 190

Beagle 165

Terrier - Bull - American Pit 150

Chihuahua 146

Retriever - Golden 126

Domestic Shorthair 122

Dog (unknown) 104

Terrier (unspecified) 100

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 1,098

Vomiting 552

Lethargy (see also Central nervous system depression in 'Neurological') 458

Other abnormal test result NOS 340

Death by euthanasia 297

Anorexia 288

Elevated alanine aminotransferase (ALT) 252

Diarrhoea 249

Lack of efficacy - NOS 238

Death 220

Cough 211

Leucocytosis NOS 208

Outcome Breakdown

Ongoing

1,773 (48.1%)

Outcome Unknown

822 (22.3%)

Recovered/Normal

533 (14.5%)

Euthanized

291 (7.9%)

Died

240 (6.5%)

Recovered with Sequela

27 (0.7%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.