Drug profile

The FDA adverse-event record for Desmopressin

76 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Desmopressin. Species, reactions, and outcomes follow.

#901 of 2,679
by report volume (all drugs)
76
adverse-event reports
14.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Desmopressin ranks #898 of 2679 by total reports (76) and #386 of 1130 by death-coded share (14.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#898
This drug, reports of 2679
#386
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Desmopressin has 76 reports now versus 74 in that prior snapshot: 2 more (2.7%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Desmopressin changes

Signature read: death-coded report count at 11 is the most distinctive stamp on Desmopressin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
76
Total Reports
11
Deaths Reported
14.5%
Death-coded share of reports

Active Ingredients

Desmopressin

Administration Routes

UnknownOralOphthalmicNasal

Species Affected

Dog 74
Human 1
Cat 1

Most Affected Breeds

Retriever - Labrador 9
Retriever - Golden 7
Beagle 3
Dog (unknown) 3
Chihuahua 3
Terrier - Tibetan 2
Hound - Basset 2
Terrier - Boston 2
Deutsche Dogge, Great Dane 2
Crossbred Canine/dog 2

Most Reported Reactions

Polydipsia 10
Decreased appetite 10
Lethargy (see also Central nervous system depression in 'Neurological') 10
Elevated serum alkaline phosphatase (SAP) 10
Elevated alanine aminotransferase (ALT) 10
Vomiting 8
Polyuria 8
Diarrhoea 7
Lack of efficacy - NOS 6
Death by euthanasia 6
Urinary tract infection 6
Weight loss 6

Outcome Breakdown

Outcome Unknown
24 (32.0%)
Ongoing
22 (29.3%)
Recovered/Normal
17 (22.7%)
Euthanized
6 (8.0%)
Died
5 (6.7%)
Recovered with Sequela
1 (1.3%)

Desmopressin Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Desmopressin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (76 here).

Similar death-coded share

Nearest other drugs by death-coded share (14.5% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Desmopressin (#901 of 2,679 by report volume); death-coded 14.5%. PlainBreed drug row · death-coded report count stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →