Drug profile

The FDA adverse-event record for Dhpp Vaccine

421 FDA reports name Dhpp Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#344 of 2,679
by report volume (all drugs)
421
adverse-event reports
7.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dhpp Vaccine ranks #344 of 2679 by total reports (421) and #676 of 1130 by death-coded share (7.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#344
This drug, reports of 2679
#676
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dhpp Vaccine has 421 reports now versus 416 in that prior snapshot: 5 more (1.2%).

Report change
+5
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dhpp Vaccine changes

Signature read: 421 reports place Dhpp Vaccine in the upper third of FDA AER volume (#344 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
421
Total Reports
31
Deaths Reported
7.4%
Death-coded share of reports

Active Ingredients

Dhpp Vaccine

Administration Routes

UnknownParenteralSubcutaneousOralIntramuscular

Species Affected

Dog 421

Most Affected Breeds

Retriever - Labrador 47
Crossbred Canine/dog 23
Shepherd Dog - German 20
Chihuahua 20
Dachshund (unspecified) 17
Pit Bull 17
Shih Tzu 16
Retriever - Golden 15
Boxer (German Boxer) 13
Shepherd Dog - Australian 12

Most Reported Reactions

Vomiting 113
Emesis 106
Lethargy (see also Central nervous system depression in 'Neurological') 93
Diarrhoea 49
Other abnormal test result NOS 27
Seizure NOS 23
Behavioural disorder NOS 22
Ataxia 21
Death 21
Decreased appetite 20
Anorexia 19
Lack of efficacy - NOS 19

Outcome Breakdown

Recovered/Normal
210 (49.9%)
Outcome Unknown
98 (23.3%)
Ongoing
63 (15.0%)
Died
23 (5.5%)
Recovered with Sequela
19 (4.5%)
Euthanized
8 (1.9%)

Dhpp Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dhpp Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dhpp Vaccine (#344 of 2,679 by report volume); death-coded 7.4%. PlainBreed drug row · report volume stamp 421 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →