Drug profile

The FDA adverse-event record for Dhpp Vaccine

408 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dhpp Vaccine. See the species affected, top reactions, and outcomes below.

408
adverse-event reports
7.1%
death-coded share
Dog
most-reported species
109
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
408
Total Reports
29
Deaths Reported
7.1%
Death Rate

Active Ingredients

Dhpp Vaccine

Administration Routes

UnknownParenteralSubcutaneousOralIntramuscular

Species Affected

Dog 408

Most Affected Breeds

Retriever - Labrador 47
Crossbred Canine/dog 22
Shepherd Dog - German 20
Chihuahua 19
Dachshund (unspecified) 17
Pit Bull 17
Shih Tzu 15
Retriever - Golden 14
Boxer (German Boxer) 11
Terrier - Yorkshire 11

Most Reported Reactions

Vomiting 109
Emesis 106
Lethargy (see also Central nervous system depression in 'Neurological') 93
Diarrhoea 47
Other abnormal test result NOS 25
Seizure NOS 22
Behavioural disorder NOS 20
Ataxia 19
Anorexia 19
Lack of efficacy - NOS 19
Decreased appetite 19
Death 19

Outcome Breakdown

Recovered/Normal
205 (50.2%)
Outcome Unknown
97 (23.8%)
Ongoing
58 (14.2%)
Died
21 (5.1%)
Recovered with Sequela
19 (4.7%)
Euthanized
8 (2.0%)

Dhpp Vaccine Adverse Event Insights

408 reports name Dhpp Vaccine; 29 recorded a death outcome (7.1% of reported events, not a population-level mortality rate). Active ingredient: Dhpp Vaccine. Administration routes: Unknown, Parenteral, Subcutaneous, Oral.

By species: Dog (408 reports). By breed: Retriever - Labrador (47), Crossbred Canine/dog (22), Shepherd Dog - German (20).

Leading clinical signs: Vomiting (109), Emesis (106), Lethargy (see also Central nervous system depression in 'Neurological') (93), Diarrhoea (47). Outcome, 408 coded reports: Recovered/Normal leads at 50.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.