Drug profile

The FDA adverse-event record for Allergy

191 FDA reports name Allergy, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#548 of 2,679
by report volume (all drugs)
191
adverse-event reports
7.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Allergy ranks #548 of 2679 by total reports (191) and #678 of 1130 by death-coded share (7.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#548
This drug, reports of 2679
#678
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Allergy has 191 reports now versus 191 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Allergy changes

Signature read: 191 reports place Allergy in the upper third of FDA AER volume (#548 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
191
Total Reports
14
Deaths Reported
7.3%
Death-coded share of reports

Active Ingredients

Allergy

Administration Routes

UnknownSubcutaneousOralSublingualIntradermal

Species Affected

Dog 185
Cat 6

Most Affected Breeds

Retriever - Labrador 23
Shih Tzu 10
Shepherd Dog - German 9
Boxer (German Boxer) 7
Terrier - Bull - American Pit 7
Retriever - Golden 7
Terrier - Yorkshire 6
Chihuahua 6
Crossbred Canine/dog 6
Terrier - Boston 6

Most Reported Reactions

Vomiting 26
Lack of efficacy - NOS 24
Lethargy (see also Central nervous system depression in 'Neurological') 20
Other abnormal test result NOS 19
Elevated serum alkaline phosphatase (SAP) 18
INEFFECTIVE, LOSS OF EFFECT 18
INEFFECTIVE, ATOPY CONTROL 16
Behavioural disorder NOS 13
Diarrhoea 12
Anorexia 9
Elevated alanine aminotransferase (ALT) 9
Seizure NOS 8

Outcome Breakdown

Ongoing
124 (64.9%)
Outcome Unknown
37 (19.4%)
Recovered/Normal
16 (8.4%)
Euthanized
8 (4.2%)
Died
6 (3.1%)

Allergy: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Allergy, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (7.3% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Allergy (#548 of 2,679 by report volume); death-coded 7.3%. PlainBreed drug row · report volume stamp 191 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →