Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On

419 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

419

Total Reports

Deaths Reported

70.0%

Death Rate

Active Ingredients

Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On

Administration Routes

UnknownTopical

Species Affected

Dog 417

Other Canids 2

Most Affected Breeds

Retriever - Labrador 71

Dog (other) 45

Siberian Husky 21

Retriever - Golden 21

Crossbred Canine/dog 21

Shepherd Dog - German 20

Shepherd Dog - Australian 13

Collie - Border 13

Sheepdog - Shetland 11

Mixed (Dog) 10

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 273

Vomiting 68

Ataxia 33

Behavioural disorder NOS 30

Diarrhoea 29

Application site irritation 22

Bradycardia 19

Anorexia 18

Application site hair loss 18

Hyperactivity 15

Application site erythema 13

Seizure NOS 13

Outcome Breakdown

Recovered/Normal

208 (49.1%)

Outcome Unknown

195 (46.0%)

Ongoing

18 (4.2%)

Euthanized

2 (0.5%)

Died

1 (0.2%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.