Drug profile

The FDA adverse-event record for Clopidogrel

142 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Clopidogrel. See the species affected, top reactions, and outcomes below.

142
adverse-event reports
21.8%
death-coded share
Dog
most-reported species
25
Death by euthanasia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
142
Total Reports
31
Deaths Reported
21.8%
Death Rate

Active Ingredients

Clopidogrel

Administration Routes

OralUnknownTopical

Species Affected

Dog 76
Cat 59
Human 7

Most Affected Breeds

Domestic Shorthair 35
Unknown 9
Beagle 8
Retriever - Golden 7
Crossbred Canine/dog 5
Terrier - Jack Russell 4
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 4
Ragdoll 4
Domestic Longhair 3
Spaniel - Cocker American 3

Most Reported Reactions

Death by euthanasia 25
Vomiting 18
Lethargy (see also Central nervous system depression in Neurological) 18
Diarrhoea 15
Proteinuria 13
Lack of efficacy - NOS 13
Not eating 13
Elevated blood urea nitrogen (BUN) 11
Elevated creatinine 9
Ataxia 9
Heart murmur 8
Decreased appetite 8

Outcome Breakdown

Outcome Unknown
47 (33.3%)
Ongoing
35 (24.8%)
Recovered/Normal
26 (18.4%)
Euthanized
25 (17.7%)
Died
6 (4.3%)
Recovered with Sequela
2 (1.4%)

Clopidogrel Adverse Event Insights

142 reports name Clopidogrel; 31 recorded a death outcome (21.8% of reported events, not a population-level mortality rate). Active ingredient: Clopidogrel. Administration routes: Oral, Unknown, Topical.

By species: Dog (76 reports), Cat (59 reports), Human (7 reports). By breed: Domestic Shorthair (35), Unknown (9), Beagle (8).

Leading clinical signs: Death by euthanasia (25), Vomiting (18), Lethargy (see also Central nervous system depression in Neurological) (18), Diarrhoea (15). Outcome, 141 coded reports: Outcome Unknown leads at 33.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.