Drug profile

The FDA adverse-event record for Clopidogrel

194 FDA reports name Clopidogrel, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#542 of 2,679
by report volume (all drugs)
194
adverse-event reports
24.2%
death-coded share
Cat
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Clopidogrel ranks #542 of 2679 by total reports (194) and #182 of 1130 by death-coded share (24.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#542
This drug, reports of 2679
#182
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Clopidogrel has 194 reports now versus 176 in that prior snapshot: 18 more (10.2%).

Report change
+18
Death-coded reports
+2
Death-coded share
−1.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Clopidogrel changes

Signature read: death-coded report count at 47 is the most distinctive stamp on Clopidogrel's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
194
Total Reports
47
Deaths Reported
24.2%
Death-coded share of reports

Active Ingredients

Clopidogrel

Administration Routes

OralUnknownTopical

Species Affected

Cat 96
Dog 91
Human 7

Most Affected Breeds

Domestic Shorthair 63
Unknown 9
Beagle 8
Retriever - Golden 7
Domestic Mediumhair 6
Ragdoll 6
Crossbred Canine/dog 5
Domestic Longhair 5
Terrier - Jack Russell 5
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 5

Most Reported Reactions

Death by euthanasia 36
Lethargy (see also Central nervous system depression in Neurological) 31
Vomiting 29
Diarrhoea 20
Not eating 19
Elevated blood urea nitrogen (BUN) 17
Weight loss 17
Proteinuria 16
Decreased appetite 16
Lack of efficacy - NOS 15
Immune mediated haemolytic anaemia 14
Elevated creatinine 14

Outcome Breakdown

Outcome Unknown
73 (37.8%)
Ongoing
41 (21.2%)
Euthanized
36 (18.7%)
Recovered/Normal
30 (15.5%)
Died
11 (5.7%)
Recovered with Sequela
2 (1.0%)

Clopidogrel: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Clopidogrel, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (24.2% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Clopidogrel (#542 of 2,679 by report volume); death-coded 24.2%. PlainBreed drug row · death-coded report count stamp 47 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →