Drug profile

The FDA adverse-event record for Penicillin G Procaine

193 FDA reports name Penicillin G Procaine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#544 of 2,679
by report volume (all drugs)
193
adverse-event reports
6.7%
death-coded share
Unknown
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Penicillin G Procaine ranks #544 of 2679 by total reports (193) and #708 of 1130 by death-coded share (6.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#544
This drug, reports of 2679
#708
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Penicillin G Procaine has 193 reports now versus 193 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Penicillin G Procaine changes

Signature read: 193 reports place Penicillin G Procaine in the upper third of FDA AER volume (#544 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
193
Total Reports
13
Deaths Reported
6.7%
Death-coded share of reports

Active Ingredients

Penicillin G Procaine

Administration Routes

UnknownSubcutaneousIntramuscularIntravenousParenteralOralOphthalmic

Species Affected

Unknown 121
Dog 40
Horse 11
Cattle 8
Cat 7
Pig 4
Other 1
Rabbit 1

Most Affected Breeds

Unknown 126
Holstein-Friesian also known as Holstein 6
Dog (unknown) 5
Quarter Horse 4
Domestic Shorthair 4
Terrier - Bull - American Pit 3
Chihuahua 3
Crossbred Porcine/Pig 2
Thoroughbred 2
Cat (unknown) 2

Most Reported Reactions

Suspension, Abnormal 72
Injection site abscess 11
Death 10
Missing Labels 8
Injection site pain 6
Dyspnoea 6
Injection site seroma 6
Product Defect, General 6
Lethargy (see also Central nervous system depression in 'Neurological') 6
Leucocytosis NOS 5
Anorexia 5
Lot # and /or Expiration date missing 5

Outcome Breakdown

Recovered/Normal
32 (46.4%)
Outcome Unknown
15 (21.7%)
Died
12 (17.4%)
Ongoing
6 (8.7%)
Recovered with Sequela
3 (4.3%)
Euthanized
1 (1.4%)

Penicillin G Procaine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Penicillin G Procaine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (6.7% here), distinct from the volume row.

What to do with this drug

  • Compare Penicillin G Procaine's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Penicillin G Procaine (#544 of 2,679 by report volume); death-coded 6.7%. PlainBreed drug row · report volume stamp 193 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →