Drug profile

The FDA adverse-event record for Piroxicam

83 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Piroxicam. See the species affected, top reactions, and outcomes below.

83
adverse-event reports
25.3%
death-coded share
Dog
most-reported species
19
Death by euthanasia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
83
Total Reports
21
Deaths Reported
25.3%
Death Rate

Active Ingredients

Piroxicam

Administration Routes

OralUnknownTopical

Species Affected

Dog 78
Cat 5

Most Affected Breeds

Retriever - Labrador 10
Domestic Shorthair 4
Beagle 4
Dog (unknown) 4
Chihuahua 3
Spitz - German Pomeranian 3
Dachshund (unspecified) 3
Spaniel (unspecified) 3
Shih Tzu 3
Crossbred Canine/dog 3

Most Reported Reactions

Death by euthanasia 19
Lethargy (see also Central nervous system depression in 'Neurological') 14
Vomiting 12
Anorexia 7
Diarrhoea 7
Abnormal radiograph finding 7
Other abnormal test result NOS 6
Anaemia NOS 6
Neoplasia NOS 6
Elevated blood urea nitrogen (BUN) 5
Ataxia 5
Panting 5

Outcome Breakdown

Ongoing
37 (45.1%)
Euthanized
19 (23.2%)
Outcome Unknown
12 (14.6%)
Recovered/Normal
12 (14.6%)
Died
2 (2.4%)

Piroxicam Adverse Event Insights

83 reports name Piroxicam; 21 recorded a death outcome (25.3% of reported events, not a population-level mortality rate). Active ingredient: Piroxicam. Administration routes: Oral, Unknown, Topical.

By species: Dog (78 reports), Cat (5 reports). By breed: Retriever - Labrador (10), Domestic Shorthair (4), Beagle (4).

Leading clinical signs: Death by euthanasia (19), Lethargy (see also Central nervous system depression in 'Neurological') (14), Vomiting (12), Anorexia (7). Outcome, 82 coded reports: Ongoing leads at 45.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.