Drug profile

The FDA adverse-event record for Cisapride

130 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cisapride. See the species affected, top reactions, and outcomes below.

130
adverse-event reports
12.3%
death-coded share
Cat
most-reported species
22
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
130
Total Reports
16
Deaths Reported
12.3%
Death Rate

Active Ingredients

Cisapride

Administration Routes

UnknownOral

Species Affected

Cat 91
Dog 39

Most Affected Breeds

Domestic Shorthair 67
Domestic Longhair 7
Domestic Mediumhair 4
Retriever - Labrador 4
Cat (other) 4
Chihuahua 3
Poodle (unspecified) 2
Poodle - Miniature 2
Maine Coon 2
Shepherd Dog - German 2

Most Reported Reactions

Vomiting 22
Weight loss 17
Decreased appetite 16
Death by euthanasia 15
Anorexia 12
Diarrhoea 12
Lack of efficacy - NOS 12
Lethargy (see also Central nervous system depression in Neurological) 11
Constipation 10
Other abnormal test result NOS 10
Lethargy (see also Central nervous system depression in 'Neurological') 10
Ataxia 9

Outcome Breakdown

Ongoing
61 (46.9%)
Outcome Unknown
33 (25.4%)
Recovered/Normal
19 (14.6%)
Euthanized
15 (11.5%)
Recovered with Sequela
1 (0.8%)
Died
1 (0.8%)

Cisapride Adverse Event Insights

130 reports name Cisapride; 16 recorded a death outcome (12.3% of reported events, not a population-level mortality rate). Active ingredient: Cisapride. Administration routes: Unknown, Oral.

By species: Cat (91 reports), Dog (39 reports). By breed: Domestic Shorthair (67), Domestic Longhair (7), Domestic Mediumhair (4).

Leading clinical signs: Vomiting (22), Weight loss (17), Decreased appetite (16), Death by euthanasia (15). Outcome, 130 coded reports: Ongoing leads at 46.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.