Drug profile

The FDA adverse-event record for Dexamethasone Sp

143 FDA reports name Dexamethasone Sp, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#646 of 2,679
by report volume (all drugs)
143
adverse-event reports
25.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dexamethasone Sp ranks #646 of 2679 by total reports (143) and #167 of 1130 by death-coded share (25.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#646
This drug, reports of 2679
#167
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dexamethasone Sp has 143 reports now versus 135 in that prior snapshot: 8 more (5.9%).

Report change
+8
Death-coded reports
+0
Death-coded share
−1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dexamethasone Sp changes

Signature read: death-coded report count at 36 is the most distinctive stamp on Dexamethasone Sp's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
143
Total Reports
36
Deaths Reported
25.2%
Death-coded share of reports

Active Ingredients

Dexamethasone Sp

Administration Routes

UnknownIntravenousIntramuscularSubcutaneousParenteralAuricular (Otic)

Species Affected

Dog 107
Cat 36

Most Affected Breeds

Domestic Shorthair 26
Retriever - Labrador 19
Shepherd Dog - German 7
Chihuahua 6
Terrier (unspecified) 6
Terrier - Yorkshire 4
Crossbred Canine/dog 4
Dachshund (unspecified) 4
Poodle (unspecified) 3
Bulldog - French 3

Most Reported Reactions

Vomiting 49
Death by euthanasia 25
Elevated alanine aminotransferase (ALT) 22
Diarrhoea 21
Not eating 21
Panting 20
Lethargy (see also Central nervous system depression in Neurological) 20
Neutrophilia 18
Pale mucous membrane 14
Lethargy (see also Central nervous system depression in 'Neurological') 14
Leucocytosis NOS 13
Other abnormal test result NOS 12

Outcome Breakdown

Ongoing
43 (30.1%)
Outcome Unknown
37 (25.9%)
Recovered/Normal
27 (18.9%)
Euthanized
24 (16.8%)
Died
12 (8.4%)

Dexamethasone Sp: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dexamethasone Sp, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (143 here).

Similar death-coded share

Nearest other drugs by death-coded share (25.2% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dexamethasone Sp (#646 of 2,679 by report volume); death-coded 25.2%. PlainBreed drug row · death-coded report count stamp 36 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →